Pyrroloquinoline quinone disodium salt 是氧化还原辅助因子,一种阴离子型氧化还原循环原醌。Pyrroloquinoline quinone disodium salt 最初是从嗜甲基细菌的培养物中分离的,也存在于哺乳动物的组织。Pyrroloquinoline quinone disodium salt 是哺乳动物的必需营养素,对免疫功能很重要。
Pyrroloquinoline quinone disodium salt Chemical Structure
CAS No. : 122628-50-6
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¥800
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25 mg
¥3100
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50 mg
¥5600
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100 mg
¥9800
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200 mg
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500 mg
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Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function[1][2].
IC50 & Target[1]
Human Endogenous Metabolite
体外研究 (In Vitro)
Mouse pups born to and nursing from Pyrroloquinoline quinone disodium salt-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
374.17
Formula
C14H4N2Na2O8
CAS 号
122628-50-6
中文名称
吡咯喹啉醌二钠盐;吡咯并喹啉苯醌钠盐
运输条件
Room temperature in continental US; may vary elsewhere.
Solubility: 5 mg/mL (13.36 mM); Suspended solution; Need ultrasonic
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
[1]. Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.
[2]. Bishop A, et al. Methoxatin (PQQ) in guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.
Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) 是动物组织和某些微生物中含有葡萄糖的寡糖、多糖、糖蛋白和糖脂的前体。Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) 是一种 P2Y14 受体 (一种神经免疫系统 GPCR) 激动剂。
Uridine 5′-diphosphoglucose disodium salt Chemical Structure
CAS No. : 28053-08-9
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;
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10;mM;*;1 mL in DMSO
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生物活性
Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[1].
分子量
610.27
Formula
C15H22N2Na2O17P2
CAS 号
28053-08-9
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-80deg;C, protect from light, stored under nitrogen
溶解性数据
In Vitro:;
H2O : ≥ 250 mg/mL (409.65 mM)
DMSO : 115 mg/mL (188.44 mM; ultrasonic and warming and heat to 60°C)
*“≥” means soluble, but saturation unknown.
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
1.6386 mL
8.1931 mL
16.3862 mL
5 mM
0.3277 mL
1.6386 mL
3.2772 mL
10 mM
0.1639 mL
0.8193 mL
1.6386 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.
[2]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5′-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.
PNPP (Para-nitrophenyl phosphate) disodium is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in ELISA and conventional spectrophotometric assays.
体外研究 (In Vitro)
Phosphatases catalyze the hydrolysis of PNPP liberating inorganic phosphate and the conjugate base of para-nitrophenol (pNP). The resulting phenolate is yellow, with a maximal absorption at 405 nm[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
263.05
Formula
C6H4NNa2O6P
CAS 号
4264-83-9
运输条件
Room temperature in continental US; may vary elsewhere.
Flavin adenine dinucleotide (FAD) disodium salt 是一种氧化还原辅因子,蛋白质的辅基,在代谢过程中参与了几个重要的酶反应。
Flavin adenine dinucleotide disodium salt Chemical Structure
CAS No. : 84366-81-4
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10;mM;*;1 mL in Water
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¥770
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生物活性
Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
IC50 Target
Human Endogenous Metabolite
;
体外研究 (In Vitro)
Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量
829.51
Formula
C27H31N9Na2O15P2
CAS 号
84366-81-4
中文名称
黄素腺嘌呤二核苷酸二钠
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4deg;C, sealed storage, away from moisture and light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;
H2O : 33.33 mg/mL (40.18 mM; Need ultrasonic)
DMSO : 5 mg/mL (6.03 mM; ultrasonic and warming and heat to 60°C)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
1.2055 mL
6.0277 mL
12.0553 mL
5 mM
0.2411 mL
1.2055 mL
2.4111 mL
10 mM
0.1206 mL
0.6028 mL
1.2055 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
参考文献
[1]. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65.
[2]. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9.
Sodium molybdate (Molybdate disodium) is a useful source of molybdate. It is often found as Sodium molybdate dihydrate. In murine models, Sodium molybdate dihydrate inactivated both the active and inactive form of the gluco corticoid receptor complex. With the use of nitrites, molybdate salts have been shown to reduce the emission of hydrogen sulfide from swine manure.
分子量
205.94
Formula
MoNa2O4
CAS 号
7631-95-0
中文名称
钼酸钠
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4deg;C, protect from light, stored under nitrogen
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;
H2O : ≥ 100 mg/mL (485.58 mM)
*“≥” means soluble, but saturation unknown.
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
4.8558 mL
24.2789 mL
48.5578 mL
5 mM
0.9712 mL
4.8558 mL
9.7116 mL
10 mM
0.4856 mL
2.4279 mL
4.8558 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
Ethylenediaminetetraacetic acid (EDTA) disodium dihydrate is a chelating agent used as a protease inhibitor and metal ion scavenger. Ethylenediaminetetraacetic acid disodium dihydrate is used extensively during protein purification. Ethylenediaminetetraacetic acid disodium dihydrate has been shown to be a noneffective molecule on cellulase activity. Ethylenediaminetetraacetic acid disodium dihydrate binds to metals including calcium and facilitates their excretion[1][2].
分子量
372.24
Formula
C10H18N2Na2O10
CAS 号
6381-92-6
中文名称
乙二胺四乙酸二钠二水合物
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20deg;C
3 years
4deg;C
2 years
In solvent
-80deg;C
6 months
-20deg;C
1 month
参考文献
[1]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016;10(1):58-62.
[2]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011;412(1):34-39.
Sulfobromophthalein (Bromosulfophthalein) disodium salt 是一种有机阴离子染料,用于研究动物组织中表达的多种膜载体,并参与药物和代谢物的运输。
Sulfobromophthalein disodium salt Chemical Structure
CAS No. : 71-67-0
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500 mg
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Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites[1].
体外研究 (In Vitro)
Sulfobromophthalein disodium salt is a synthetic dye introduced in 1925 as a clinical tool aiming at the assessment of the liver function[1]. Sulfobromophthalein (BSP) is a pH indicator dye, featured by fast (17), protondependent quinoidal–phenolic tautomerism (pK = 8.5) [1]. Bromosulfalein has been commonly used as both a substrate and inhibitor of organic anionic transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, and OATP2B1, as well as multidrug resistance protein 2 (MDR2) [2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
838.00
Formula
C20H8Br4Na2O10S2
CAS 号
71-67-0
运输条件
Room temperature in continental US; may vary elsewhere.