标签归档：diprotin

Diprotin A TFA(Synonyms: Ile-Pro-Ile TFA)

发表于由

Diprotin A TFA;(Synonyms: Ile-Pro-Ile TFA) 纯度: 98.80%

Diprotin A TFA (Ile-Pro-Ile TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。

Diprotin A TFAamp;;(Synonyms: Ile-Pro-Ile TFA)

Diprotin A TFA Chemical Structure

CAS No. : 209248-71-5

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥715 In-stock
5 mg ￥650 In-stock
10 mg ￥990 In-stock
25 mg ￥2100 In-stock
50 mg ￥2900 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

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Diprotin A TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Peptidomimetic Library
  • Diabetes Related Compound Library
  • Peptide Library

生物活性

Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].

IC50 Target

DPP-IV[1].
体外研究
(In Vitro)

Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

455.47

Formula

C19H32F3N3O6
CAS 号

209248-71-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 77.5 mg/mL (170.15 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1955 mL 10.9777 mL 21.9553 mL
5 mM 0.4391 mL 2.1955 mL 4.3911 mL
10 mM 0.2196 mL 1.0978 mL 2.1955 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.