Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.
分子量
682.67
Formula
C32H42O16
CAS 号
63902-38-5
中文名称
松脂醇二葡萄糖苷
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Song JZ, et al. Development and validation of an ultra high-performance liquid chromatographic method for the determination of a diastereomeric impurity in (+)-pinoresinol diglucoside chemical reference substance. J Sep Sci. 2010 Jul;33(13):1909-15.
[2]. Zhang Y, et al. Production of pinoresinol diglucoside, pinoresinol monoglucoside, and pinoresinol by Phomopsis sp. XP-8 using mung bean and its major components. Appl Microbiol Biotechnol. 2015 Mar 25.
[3]. Shi J, et al. Structure identification and fermentation characteristics of pinoresinol diglucoside produced by Phomopsis sp. isolated from Eucommia ulmoides Oliv. Appl Microbiol Biotechnol. 2012 Feb;93(4):1475-83.
Secoisolariciresinol diglucoside Chemical Structure
CAS No. : 257930-74-8
规格
价格
是否有货
数量
10;mM;*;1 mL in Water
¥1209
In-stock
5 mg
¥800
In-stock
10 mg
¥1400
In-stock
25 mg
¥2800
In-stock
50 mg
¥3900
In-stock
100 mg
¥6700
In-stock
200 mg
;
询价
;
500 mg
;
询价
;
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Secoisolariciresinol diglucoside 相关产品
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生物活性
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects[1][2].
体外研究 (In Vitro)
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals[1]. Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Hand feeding mice (10 weeks old, male) are injected with TNFα[2]
Dosage:
4 mg/mouse
Administration:
P.o. 2 h before i.c. administration of TNFα
Result:
Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.
分子量
686.70
Formula
C32H46O16
CAS 号
257930-74-8
中文名称
亚麻木酚素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8.
[2]. Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25.
(R,R)-Secoisolariciresinol diglucoside Chemical Structure
CAS No. : 158932-33-3
规格
价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥755
In-stock
5 mg
¥500
In-stock
10 mg
¥800
In-stock
20 mg
¥1400
In-stock
50 mg
;
询价
;
100 mg
;
询价
;
* Please select Quantity before adding items.
(R,R)-Secoisolariciresinol diglucoside 相关产品
bull;相关化合物库:
Natural Product Library Plus
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Immunology/Inflammation Compound Library
Natural Product Library
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生物活性
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells[1][2][3].
分子量
686.70
Formula
C32H46O16
CAS 号
158932-33-3
中文名称
(R,R)-亚麻木酚素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Mishra OP, et al. Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage. Radiat Res. 2014 Jul;182(1):102-10.
[2]. Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8.
[3]. Mishra OP, et al. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells. Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1364-1375.
Kaempferol 3,4′-diglucoside is a flavonol isolated from the aqueous methanolic extract of norway spruce buds. Kaempferol 3,4′-diglucoside is identified in the needles[1].
IC50 Target[1]
Human Endogenous Metabolite
;
分子量
610.52
Formula
C27H30O16
CAS 号
71939-16-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Slimestad R., et al. Syringetin 3-O-(6″-acetyl)-β-glucopyranoside and other flavonols from needles of norway spruce, Picea abies. Phytochemistry. 1995;40(5):1537-1542.