标签归档：derivative

Cyclosporin A-Derivative 1

发表于由

Cyclosporin A-Derivative 1;

Cyclosporin A-Derivative 1 是环孢菌素 A 衍生的结晶中间体，来自专利 WO 2013167703 A1。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。

Cyclosporin A-Derivative 1amp;;

Cyclosporin A-Derivative 1 Chemical Structure

CAS No. : 1487360-85-9

规格 价格 是否有货
1 mg ￥1500 询问价格 货期
5 mg ￥3500 询问价格 货期

* Please select Quantity before adding items.

Cyclosporin A-Derivative 1 的其他形式现货产品:

Cyclosporin A-Derivative 1 Free base

生物活性

Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

体外研究
(In Vitro)

Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporine A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1364.50

Formula

C65H118BF4N11O14
CAS 号

1487360-85-9
Sequence

Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}
Sequence Shortening

LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Fabrice Gallou, et al. Process for the manufacture of cyclic undecapeptides. WO 2013167703 A1.

Cyclosporin A-Derivative 1 Free base

发表于由

Cyclosporin A-Derivative 1 Free base; 纯度: 99.29%

Cyclosporin A-Derivative 1 (Free base) 是环孢菌素 A 衍生的结晶中间体，来自专利 WO 2013167703 A1。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。

Cyclosporin A-Derivative 1 Free baseamp;;

Cyclosporin A-Derivative 1 Free base Chemical Structure

CAS No. : 286852-20-8

规格 价格 是否有货 数量
1 mg ￥1500 In-stock
5 mg ￥3500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Cyclosporin A-Derivative 1 Free base 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

体外研究
(In Vitro)

Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporin A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1276.69

Formula

C65H117N11O14
CAS 号

286852-20-8
Sequence

Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}
Sequence Shortening

LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Fabrice Gallou, et al. Process for the manufacture of cyclic undecapeptides. WO 2013167703 A1.

Exendin derivative 1

发表于由

Exendin derivative 1; 纯度: 98.94%

Exendin derivative 1 是由 39 个氨基酸组成的多肽。

Exendin derivative 1amp;;

Exendin derivative 1 Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1100 In-stock
5 mg ￥2200 In-stock
10 mg ￥3500 In-stock
25 mg ￥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Exendin derivative 1 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Exendin derivative 1 is a 39 amino acid peptide.

分子量

4187.56

Formula

C184H281N49O61S
Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Leu-Met-Asn-Pro-Gln-Arg-Ser-Thr-Val-Trp-Tyr
Sequence Shortening

HAEGTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPSLMNPQRSTVWY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (11.94 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2388 mL 1.1940 mL 2.3880 mL
5 mM 0.0478 mL 0.2388 mL 0.4776 mL
10 mM 0.0239 mL 0.1194 mL 0.2388 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

Cyclosporin A-Derivative 2

发表于由

Cyclosporin A-Derivative 2;

Cyclosporin A-Derivative 2 是 Cyclosporin A 的新型衍生物。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。

Cyclosporin A-Derivative 2amp;;

Cyclosporin A-Derivative 2 Chemical Structure

CAS No. : 156047-45-9

规格 价格 是否有货
1 mg ￥2100 询问价格 货期
5 mg ￥6500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

分子量

1149.51

Formula

C58H104N10O13
CAS 号

156047-45-9
Sequence Shortening

VLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Peel M, et al. Cyclophilin inhibitors as antiviral agents. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4485-92.