标签归档：dap

ShK-Dap22 TFA

发表于由

ShK-Dap22 TFA;

ShK-Dap22 TFA 是一种有效的特异性 Kv1.3 免疫抑制多肽。ShK-Dap22 TFA 是一种选择性 Kv1.3 通道阻滞剂，对 mKv1.3，mKv1.1，hKv1.6，mKv1.4，和 rKv1.2 通道的 IC50 分别为 23 pM，1.8 nM，10.5 nM，37 nM，和 39 nM。

ShK-Dap22 TFAamp;;

ShK-Dap22 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

ShK-Dap22 TFA is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 TFA is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].

体外研究
(In Vitro)

ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4126.71

Formula

C168H269F3N54O50S7
Sequence

Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-{Dpr}-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (Disulfide bridge:Cys3-Cys35;Cys12-Cys28;Cys17-Cys32)
Sequence Shortening

RSCIDTIPKSRCTAFQCKHSM{Dpr}YRLSFCRKTCGTC (Disulfide bridge:Cys3-Cys35;Cys12-Cys28;Cys17-Cys32)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. K Kalman, et al. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707.

14:0 DAP

发表于由

生化分析试剂 Biochemical Assay Reagents
14:0 DAP;

14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) 是一种阳离子脂质，可用于药物递送。

14:0 DAP

14:0 DAP Chemical Structure

CAS No. : 72719-84-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery[1].

分子量

539.87

Formula

C33H65NO4
CAS 号

72719-84-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. F Nomura, et al. Capabilities of liposomes for topological transformation. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2340-5.

18:0 DAP

发表于由

生化分析试剂 Biochemical Assay Reagents
18:0 DAP;

18:0 DAP 可用于制备脂质纳米粒 (LNPs)，mRNA 被包裹在其核心。

18:0 DAP

18:0 DAP Chemical Structure

CAS No. : 121315-93-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

18:0 DAP can be used to formulate lipid nanoparticles (LNPs), which mRNA is encapsulated in their core[1].

分子量

652.09

Formula

C41H81NO4
CAS 号

121315-93-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Patel S, et al. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019;303:91-100.