DAMGO; 纯度: 99.61%
DAMGO 是 一种选择性的 μ-阿片受体 (μ-OPR) 激动剂,Kd 值为 3.46 nM。
DAMGO Chemical Structure
CAS No. : 78123-71-4
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥1119 | In-stock | |
1 mg | ¥600 | In-stock | |
5 mg | ¥990 | In-stock | |
10 mg | ¥1700 | In-stock | |
25 mg | ¥3700 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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DAMGO 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Neuronal Signaling Compound Library
- Anti-Cancer Compound Library
- Neurotransmitter Receptor Compound Library
- Neuroprotective Compound Library
- Peptide Library
生物活性 |
DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1]. |
IC50 Target |
Kd: 3.46±0.84 nM (native μ-OPR)[1] |
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体外研究 (In Vitro) |
DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. In native μ-OPR, the Kd value for DAMGO is 3.46± 0.84 nM (n=3). The chimeric receptor MMDD, in which the carboxy-terminal half of μ-OPR is replaced with the corresponding region of δ-OPR, exhibits an equivalent affinity (Kd=2.13±0.40 nM; n=3) to DAMGO compared with the native μ-OPR[1]. DAMGO is a selective μ-opioid peptide. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies. Regulation of neuronal response to CXCL12 is essential for shaping of developing and mature central nervous system (CNS). To establish whether DAMGO alter the effect of CXCL12 on neuronal survival, the ability of CXCL12 to protect neurons from N-methyl-d-aspartate (NMDA)-induced death is examined in the presence and absence of DAMGO. Cortical cultures are treated with DAMGO (1 and 10 μM). Neurons are subsequently exposed to NMDA (20 min) and/or CXCL12 (added 10 min before NMDA) in the absence of glia and then returned to the original culture dishes with the glial feeder layer. Neuronal death is evaluated after 24 h. DAMGO inhibits neuronal survival promoted by CXCL12[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
513.59 |
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Formula |
C26H35N5O6 |
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CAS 号 |
78123-71-4 |
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Sequence |
Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol |
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Sequence Shortening |
Y-{d-Ala}-G-{Me-Phe}-G-ol |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Protect from light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:;
DMSO : 33.33 mg/mL (64.90 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [2] |
Neurons (9 days in vitro) are treated with DAMGO (10 μM) for 24 h in their original culture dish, subsequently transferred to a dish containing Mg2+-free saline with glycine (15 μM), and exposed to NMDA (100 μM) and/or CXCL12 (20 nM) in absence of glia. After treatments, neurons are moved back into the original culture dishes containing glia. Neuronal death is evaluated after 24 h. Hoechst 33342 (3 μg/mL) combined with cleaved caspase-3 (1:100) staining is used to identify normal and apoptotic cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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