标签归档：cyclic

CTTHWGFTLC, CYCLIC

发表于由

CTTHWGFTLC, CYCLIC;

CTTHWGFTLC, CYCLIC 是一种基质金属蛋白酶 MMP-2 和 MMP-9 的环肽抑制剂。对 MMP-9 的 IC50 约为 8 μM。

CTTHWGFTLC, CYCLICamp;;

CTTHWGFTLC, CYCLIC Chemical Structure

CAS No. : 244082-19-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].

IC50 Target

MMP-9

;

MMP-2

;

体外研究
(In Vitro)

CTTHWGFTLC, CYCLIC inhibits endothelial and tumor cell migration in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

CTTHWGFTLC, CYCLIC inhibits tumor progression in vivo, in mouse models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1166.33

Formula

C52H71N13O14S2
CAS 号

244082-19-7
Sequence

Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys (Disulfide Bridge: Cys1-Cys10)
Sequence Shortening

CTTHWGFTLC (Disulfide Bridge: Cys1-Cys10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85.

Cyclic nona-L-arginine TFA

发表于由

Cyclic nona-L-arginine TFA;

Cyclic nona-L-arginine TFA 可用于药物转运，其转运速度优于线性分子。

Cyclic nona-L-arginine TFAamp;;

Cyclic nona-L-arginine TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts[1].

分子量

1519.69

Formula

C56H109F3N36O11
Sequence Shortening

Cyclic(RRRRRRRRR)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuan Hu, et al. Translocation thermodynamics of linear and cyclic nonaarginine into model DPPC bilayer via coarse-grained molecular dynamics simulation: implications of pore formation and nonadditivity. J Phys Chem B. 2014 Mar 13;118(10):2670-82.

CTTHWGFTLC, CYCLIC TFA

发表于由

CTTHWGFTLC, CYCLIC TFA;

CTTHWGFTLC, CYCLIC TFA 是一种基质金属蛋白酶 MMP-2 和 MMP-9 的环肽抑制剂。对 MMP-9 的 IC50 约为 8 μM。

CTTHWGFTLC, CYCLIC TFAamp;;

CTTHWGFTLC, CYCLIC TFA Chemical Structure

规格 价格 是否有货
1 mg ￥1400 询问价格 货期
5 mg ￥3400 询问价格 货期
10 mg ￥6300 询问价格 货期

* Please select Quantity before adding items.

生物活性

CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].

IC50 Target

MMP-2

;

MMP-9

;

体外研究
(In Vitro)

CTTHWGFTLC, CYCLIC TFA inhibits endothelial and tumor cell migration in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

CTTHWGFTLC, CYCLIC TFA inhibits tumor progression in vivo, in mouse models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1280.35

Formula

C54H72F3N13O16S2
Sequence

Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys (Disulfide Bridge: Cys1-Cys10)
Sequence Shortening

CTTHWGFTLC (Disulfide Bridge: Cys1-Cys10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85.

Cyclic MKEY

发表于由

Cyclic MKEY;

Cyclic MKEY 是 CXCL4-CCL5 异二聚体形成的合成环肽抑制剂，其通过介导炎症来防止动脉粥样硬化和主动脉瘤形成。Cyclic MKEY 还可以预防小鼠中风引起的脑损伤。

Cyclic MKEYamp;;

Cyclic MKEY Chemical Structure

CAS No. : 934385-55-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice[1][2].

IC50 Target

CXCL4-CCL5 heterodimer formation[1]
分子量

2532.89

Formula

C113H174N28O34S2
CAS 号

934385-55-4
Sequence Shortening

CKEYFYTSSKSSNLAVVFVTRC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615.

    [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.

Cyclic nona-L-arginine hydrochloride

发表于由

Cyclic nona-L-arginine hydrochloride;

Cyclic nona-L-arginine hydrochloride 可用于药物转运，其转运速度优于线性分子。

Cyclic nona-L-arginine hydrochlorideamp;;

Cyclic nona-L-arginine hydrochloride Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts[1].

分子量

1442.13

Formula

C54H109ClN36O9
Sequence Shortening

Cyclic(RRRRRRRRR)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuan Hu, et al. Translocation thermodynamics of linear and cyclic nonaarginine into model DPPC bilayer via coarse-grained molecular dynamics simulation: implications of pore formation and nonadditivity. J Phys Chem B. 2014 Mar 13;118(10):2670-82.

Cyclic MKEY TFA

发表于由

Cyclic MKEY TFA;

Cyclic MKEY TFA 是 CXCL4-CCL5 异二聚体形成的合成环肽抑制剂，其通过介导炎症来防止动脉粥样硬化和主动脉瘤形成。Cyclic MKEY TFA 还可以预防小鼠中风引起的脑损伤。

Cyclic MKEY TFAamp;;

Cyclic MKEY TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice[1][2].

IC50 Target

CXCL4-CCL5[1]
分子量

2646.91

Formula

C115H175N28F3O36S2
Sequence Shortening

CKEYFYTSSKSSNLAVVFVTRC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615.

    [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.

Cyclic AMP(Synonyms: 环磷腺苷; Cyclic adenosine monophosphate; Adenosine cyclic 3′, 5′-monophosphate; cAMP)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Cyclic AMP;(Synonyms: 环磷腺苷; Cyclic adenosine monophosphate; Adenosine cyclic 3′, 5′-monophosphate; cAMP) 纯度: 99.94%

Cyclic AMP (cAMP) 是有丝分裂信使，在细胞周期中能够促进 G1 期到 S 期的过程。

Cyclic AMP(Synonyms: 环磷腺苷; Cyclic adenosine monophosphate; Adenosine cyclic 3

Cyclic AMP Chemical Structure

CAS No. : 60-92-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
500 mg ￥800 In-stock
1 g ￥1200 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

Cyclic AMP 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • Nucleotide Compound Library
  • Alkaloids Library
  • Gut Microbial Metabolite Library
  • Microbial Metabolite Library
  • Food-Sourced Compound Library
  • Rare Diseases Drug Library

生物活性

Cyclic AMP (cAMP) is a mitogenic messenger and promotes the G1 to S phase transition in the cell cycle.

IC50 Target

Human Endogenous Metabolite

;

Clinical Trial

分子量

329.21

Formula

C10H12N5O6P
CAS 号

60-92-4
中文名称

环磷腺苷；环磷酸腺苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

0.1 M NaOH : 30 mg/mL (91.13 mM; ultrasonic and adjust pH to 6 with NaOH)

H2O : 2.4 mg/mL (7.29 mM; Need ultrasonic)

DMSO : 1 mg/mL (3.04 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0376 mL 15.1879 mL 30.3757 mL
5 mM 0.6075 mL 3.0376 mL 6.0751 mL
10 mM 0.3038 mL 1.5188 mL 3.0376 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Cook SJ, et al. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 1993 Nov 12;262(5136):1069-72.

Cyclic somatostatin(Synonyms: 环状生长激素抑制素 SRIF-14 Somatostatin-14)

发表于由

Cyclic somatostatin;(Synonyms: 环状生长激素抑制素; SRIF-14; Somatostatin-14) 纯度: 99.77%

Cyclic somatostatin (SRIF-14) 是一种生长激素释放抑制因子，可用于胃十二指肠溃疡出血研究。

Cyclic somatostatinamp;;(Synonyms: 环状生长激素抑制素; SRIF-14; Somatostatin-14)

Cyclic somatostatin Chemical Structure

CAS No. : 38916-34-6

规格 价格 是否有货 数量
1 mg ￥450 In-stock
5 mg ￥650 In-stock
10 mg ￥750 In-stock
25 mg ￥900 In-stock
50 mg ￥1200 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

* Please select Quantity before adding items.

Cyclic somatostatin 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Cyclic somatostatin is a growth hormone-release inhibiting factor used in the treatment of severe, acute hemorrhages of gastroduodenal ulcers.

分子量

1637.88

Formula

C76H104N18O19S2
CAS 号

38916-34-6
Sequence Shortening

HAGCKNFFWKTFTSC-OH (Disulfide bridge: Cys3-Cys14)
中文名称

环状生长激素抑制素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

DMF : 100 mg/mL (61.05 mM; Need ultrasonic)

H2O : 71.3 mg/mL (43.53 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6105 mL 3.0527 mL 6.1055 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL
10 mM 0.0611 mL 0.3053 mL 0.6105 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

Cyclic N-Acetyl-D-mannosamine(Synonyms: Cyclic ManNAc)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Cyclic N-Acetyl-D-mannosamine;(Synonyms: Cyclic ManNAc) 纯度: ge;95.0%

Cyclic N-Acetyl-D-mannosamine (Cyclic ManNAc) 是一种内源性代谢产物。

Cyclic N-Acetyl-D-mannosamine(Synonyms: Cyclic ManNAc)

Cyclic N-Acetyl-D-mannosamine Chemical Structure

CAS No. : 7772-94-3

规格 价格 是否有货 数量
500 mg ￥350 In-stock
1 g ￥520 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

Cyclic N-Acetyl-D-mannosamine 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Gut Microbial Metabolite Library
  • Microbial Metabolite Library
  • Food-Sourced Compound Library

生物活性

Cyclic N-Acetyl-D-mannosamine (Cyclic ManNAc) is an endogenous metabolite.

分子量

221.21

Formula

C8H15NO6
CAS 号

7772-94-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (452.06 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5206 mL 22.6030 mL 45.2059 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL
10 mM 0.4521 mL 2.2603 mL 4.5206 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (11.30 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.30 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.30 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.30 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.30 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.30 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

Cyclic-[Mpr3,Nle4,Arg5,D-Nal7,Cys11-Amide]-alpha-MSH (3-11) / JKC-366 品牌：Anygen

发表于由

Cyclic-[Mpr3,Nle4,Arg5,D-Nal7,Cys11-Amide]-alpha-MSH (3-11) / JKC-366

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

304-89971

 – 0.5 mg – 咨询 – –


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