天然产物 黄酮类 Flavonoids
Xanthohumol 纯度: 99.84%
Xanthohumol 是从啤酒花中分离到的黄酮类化合物,是 DGAT,COX-1 和 COX-2 的抑制剂,具有抗肿瘤,抗血管生成的作用。Xanthohumol 还具有抗牛病毒性腹泻病毒 (BVDV),鼻病毒,HSV-1,HSV-2 和 巨细胞病毒 (CMV) 的抗病毒活性。
Xanthohumol Chemical Structure
CAS No. : 6754-58-1
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥770 | In-stock | |
5 mg | ¥700 | In-stock | |
10 mg | ¥1200 | In-stock | |
25 mg | ¥2600 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Xanthohumol 相关产品
•相关化合物库:
- Natural Product Library Plus
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- Apoptosis Compound Library
- Immunology/Inflammation Compound Library
- Metabolism/Protease Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Clinical Compound Library
- Antiviral Compound Library
- Anti-Aging Compound Library
- Drug Repurposing Compound Library
- Phenols Library
- Pyroptosis Compound Library
- Flavonoids Library
- Anti-Pancreatic Cancer Compound Library
- Anti-Obesity Compound Library
- Lipid Metabolism Compound Library
- Food-Sourced Compound Library
- Rare Diseases Drug Library
- Anti-Colorectal Cancer Compound Library
生物活性 |
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV). |
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IC50 & Target[1][2][3][4][5] |
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体外研究 (In Vitro) |
Xanthohumol significantly attenuates ADP-induced blood platelet aggregation, and significantly reduces the expression of fibrinogen receptor (activated form of GPIIbIIIa) on platelets’ surface[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
354.40 |
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Formula |
C21H22O5 |
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CAS 号 |
6754-58-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 83.33 mg/mL (235.13 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [3] |
In vitro cell proliferation/viability is measured by the MTT test at different time points. 1000 cells/well are plated into 96-multiwell plates in complete medium. Following adhesion, medium is replaced with fresh medium containing the different treatments or vehicle (DMSO in medium). Xanthohumol and EGCG are used in a concentration range from 2.5 to 40 μM, up to 96 hours. 3 hours before each time point, MTT reagent (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) is added to the wells and plates are incubated at 37°C. At the indicated time points, absorbance at 540 nm is then measured by a FLUOstar spectrophotometer. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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