标签归档：corticotropin

Corticotropin-releasing factor (human) (acetate)(Synonyms: Human CRF acetate Human corticotropin-releasing factor acetate)

发表于由

Corticotropin-releasing factor (human) (acetate);(Synonyms: Human CRF acetate; Human corticotropin-releasing factor acetate) 纯度: 98.25%

Corticotropin-releasing factor human acetate (Human CRF acetate) 能够刺激垂体前叶的促肾上腺皮质激素的合成和分泌。

Corticotropin-releasing factor (human) (acetate)amp;;(Synonyms: Human CRF acetate; Human corticotropin-releasing factor acetate)

Corticotropin-releasing factor (human) (acetate) Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1600 In-stock
5 mg ￥5600 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Corticotropin-releasing factor (human) (acetate) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Corticotropin-releasing factor human acetate (Human CRF acetate) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

体外研究
(In Vitro)

CRF increases excitability of type II dlBNST neurons through activation of the AC-cAMP-PKA pathway, thereby causing pain-induced aversive responses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In rats injected with CRF (1 nmol/side), the time spent in the drug-paired compartment during the test session (314±22 s) is significantly shorter than time spent in that compartment during the preconditioning session (520±18 s)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4817.50

Formula

C210H348N60O65S2
Sequence Shortening

SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2
中文名称

促肾上腺皮质激素释放因子醋酸盐 (人)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Kaneko T et al. Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factorwithin the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion. Eur J Neurosci. 2016 Sep 30.

    [2]. Tenk J et al. Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender. Peptides. 2016 Nov;85:63-72.

Corticotropin-releasing factor (human)(Synonyms: Human CRF Human corticotropin-releasing factor)

发表于由

Corticotropin-releasing factor (human);(Synonyms: Human CRF; Human corticotropin-releasing factor) 纯度: 98.44%

Corticotropin-releasing factor human (Human CRF) 能够刺激垂体前叶的促肾上腺皮质激素的合成和分泌。

Corticotropin-releasing factor (human) (Synonyms: Human CRF; Human corticotropin-releasing factor)

Corticotropin-releasing factor (human) Chemical Structure

CAS No. : 86784-80-7

规格 价格 是否有货 数量
250 μg ￥650 In-stock
500 μg ￥1000 In-stock
1 mg ￥1600 In-stock
5 mg ￥5600 In-stock
10 mg ￥9500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Corticotropin-releasing factor (human) 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

体外研究
(In Vitro)

CRF increases excitability of type II dlBNST neurons through activation of the AC-cAMP-PKA pathway, thereby causing pain-induced aversive responses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In rats injected with CRF (1 nmol/side), the time spent in the drug-paired compartment during the test session (314±22 s) is significantly shorter than time spent in that compartment during the preconditioning session (520±18 s)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4757.45

Formula

C208H344N60O63S2
CAS 号

86784-80-7
Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
Sequence Shortening

SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2
中文名称

促肾上腺皮质激素释放因子 (人)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:;

H2O : 25 mg/mL (5.25 mM; ultrasonic and adjust pH to 2 with HCl)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2102 mL 1.0510 mL 2.1020 mL
5 mM 0.0420 mL 0.2102 mL 0.4204 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kaneko T et al. Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factorwithin the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion. Eur J Neurosci. 2016 Sep 30.

    [2]. Tenk J et al. Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender. Peptides. 2016 Nov;85:63-72.

Tyrosyl-Corticotropin Releasing Factor 品牌：Peptide

发表于由

Tyrosyl-Corticotropin Releasing Factor

品牌：Peptide
CAS No.：100513-58-4
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-41411

 – 0.1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Corticotropin Releasing Factor (CRF) Antagonist(Alpha-HelicalCRF(9-41)) 品牌：Anygen

发表于由

Corticotropin Releasing Factor (CRF) Antagonist(Alpha-HelicalCRF(9-41))

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

303-36451

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

ACTH (7-38) / [Corticotropin Inhibiting Peptide (CIP)](Human) 品牌：Anygen

发表于由

ACTH (7-38) / [Corticotropin Inhibiting Peptide (CIP)](Human)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

309-91511

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。