天然产物 糖类和糖苷 Saccharides and Glycosides
Complanatoside A;(Synonyms: 沙苑子苷 A)
Complanatoside A是从黄芪分离的黄酮醇糖苷，目前它被用作2010版中国药典 A. complanatus 的质量控制指数。
Complanatoside A Chemical Structure
CAS No. : 146501-37-3
| 规格 | 是否有货 | ||
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| 5 mg | 询价 | ||
| 10 mg | 询价 | ||
| 25 mg | 询价 |
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| 生物活性 |
Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia. |
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| 体外研究 (In Vitro) |
A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9–103.0%) and extraction recovery is reproducible (88.5–94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
642.52 |
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| Formula |
C27H30O18 |
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| CAS 号 |
146501-37-3 |
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| 中文名称 |
沙苑子苷 A |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 溶解性数据 |
In Vitro:;
DMSO : ≥ 35.7 mg/mL (55.56 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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| 参考文献 |
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| Animal Administration [1] |
Rats: The rats are fasted for 12 h before the experiment. Complanatoside A is formulated in water and a single dose of 30 mg/kg is administered by oral gavage. Blood samples are obtained from the vena orbitalis just prior to dose and at 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 3, 5, 7, 10 and 14 h after administration. After centrifugation at 6000g for 10 min, the upper plasma is collected and stored at–20°C before analysis. The data are calculated by DrugStatistics software[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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