标签归档：cimicifugoside

Cimicifugoside

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Cimicifugoside;

Cimicifugoside 是一种从升麻单胞菌 Cimicifuga simplex 中提取的三萜类化合物，是一种新型特异性核苷转运 (nucleoside transport) 抑制剂，协同增强甲氨蝶呤细胞毒性作用。Cimicifugoside 具有免疫抑制活性，其优先针对 B 细胞功能，需要较大剂量来抑制 T 细胞功能。

Cimicifugoside

Cimicifugoside Chemical Structure

CAS No. : 66176-93-0

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生物活性

Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].

IC50 Target

Nucleoside transport[1]
分子量

674.82

Formula

C37H54O11
CAS 号

66176-93-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61.

    [2]. Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8.

Cimicifugoside H-1(Synonyms: Cimicidanol-3-O-β-d-xyloside)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Cimicifugoside H-1 (Synonyms: Cimicidanol-3-O-β-d-xyloside)

Cimicifugoside H-1，一种环甾烷醇木糖苷，是 C. foetida L.C 提取物的主要成分。Cimicifugoside H-1 可以抑制骨吸收和卵巢切除术引起的骨质流失。

Cimicifugoside H-1(Synonyms: Cimicidanol-3-O-β-d-xyloside)

Cimicifugoside H-1 Chemical Structure

CAS No. : 163046-73-9

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5 mg 询价
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25 mg 询价

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生物活性

Cimicifugoside H-1, a cyclolanostanol xyloside, is a major constituent of C. foetida L. extract. Cimicifugoside H-1 inhibits bone resorption and ovariectomy-induced bone loss[1][2][3].

分子量

616.78

Formula

C35H52O9
CAS 号

163046-73-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Koeda M, et, al. Studies on the Chinese crude drug “shoma.” IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from cimicifuga rhizome. Chem Pharm Bull (Tokyo). 1995 May;43(5):771-6.

    [2]. Gai YY, et, al. Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats. J Ethnopharmacol. 2012 Aug 30;143(1):249-55.

    [3]. Li JX, et, al. Triterpenoids from Cimicifugae rhizoma, a novel class of inhibitors on bone resorption and ovariectomy-induced bone loss. Maturitas. 2007 Sep 20;58(1):59-69.