标签归档：cholecystokinin

Cholecystokinin Octapeptide, desulfated(Synonyms: CCK Octapeptide, desulfated)

发表于由

Cholecystokinin Octapeptide, desulfated;(Synonyms: CCK Octapeptide, desulfated)

Cholecystokinin Octapeptide, desulfated 是一种合成的脱硫的八肽胆囊收缩素 (CCK)。

Cholecystokinin Octapeptide, desulfatedamp;;(Synonyms: CCK Octapeptide, desulfated)

Cholecystokinin Octapeptide, desulfated Chemical Structure

CAS No. : 25679-24-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Cholecystokinin Octapeptide, desulfated 的其他形式现货产品:

Cholecystokinin Octapeptide, desulfated TFA

生物活性

Cholecystokinin Octapeptide, desulfated is a synthetic desulfated octapeptides of cholecystokinin (CCK)[1].

分子量

1063.21

Formula

C49H62N10O13S2
CAS 号

25679-24-7
Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2
Sequence Shortening

DYMGWMDF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. L R Johnson, et al. Effect of sulfation on the gastrointestinal actions of caerulein. Gastroenterology. 1970 Feb;58(2):208-16.

Tetragastrin(Synonyms: Cholecystokinin tetrapeptide CCK-4)

发表于由

Tetragastrin;(Synonyms: Cholecystokinin tetrapeptide; CCK-4) 纯度: 99.60%

Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) 是胃泌素的 C-末端四肽，能刺激胃液分泌。Tetragastrin 是一种胆囊收缩素 (CCK-4) 受体激动剂。Tetragastrin 具有胃黏膜保护。

Tetragastrinamp;;(Synonyms: Cholecystokinin tetrapeptide; CCK-4)

Tetragastrin Chemical Structure

CAS No. : 1947-37-1

规格 价格 是否有货 数量
25 mg ￥1200 In-stock
50 mg ￥1900 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

* Please select Quantity before adding items.

Tetragastrin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Neurotransmitter Receptor Compound Library
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  • Food-Sourced Compound Library

生物活性

Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion[1]. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist[2]. Gastric mucosal protection[3].

体外研究
(In Vitro)

The antagonist of histamine H2-receptors, Cimetidine inhibits the stimulatory effect of histamine in vitro and activates Tetragastrin stimulation of the adenylate cyclase activity. Tetragastrin and histamine activate adenylate cyclase of the rat gastric mucosa via different receptors[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In inbred Wistar rats treated with N-methyl-N’-nitro-N-nitrosoguanidine, Tetragastrin (s.c.; 1 mg/kg; every other day) treatment significantly reduces the incidence and the number of adenocarcinomas, and has a significantly lower labelling index of the antral mucosa[1].
Tetragastrin has potential for enhancing gastric mucosal protection associated with mucus secretion and/or mucus synthesis on the surface mucosa of rat gastric mucosa. A significant increase in the mucin content was noted in the mucus gel and surface mucosal layer. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of Tetragastrin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male Wistar rats, each weighing approximately 160 g[3]
Dosage: 12, 120, or 400 μg/kg
Administration: Administered subcutaneously (s.c.); followed by 50% ethanol-induced gastric injury
Result: Caused a significant increase in mucin content in the corpus mucosa and prevented 50% ethanol-induced gastric mucosal damage in a dose-dependent manner.

分子量

596.70

Formula

C29H36N6O6S
CAS 号

1947-37-1
Sequence Shortening

WMDF-NH2
中文名称

四肽胃泌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 50 mg/mL (83.79 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6759 mL 8.3794 mL 16.7588 mL
5 mM 0.3352 mL 1.6759 mL 3.3518 mL
10 mM 0.1676 mL 0.8379 mL 1.6759 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.19 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.19 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.19 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.19 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.19 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.19 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. M Tatsuta, et al. Effect of 6-hydroxydopamine on gastric carcinogenesis and tetragastrin inhibition of gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res. 1989 Aug 1;49(15):4199-203.

    [2]. Nathalie Lara, et al. Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks. Neuropsychopharmacology. 2003 Oct;28(10):1840-5.

    [3]. Y Komuro,et al. Effects of tetragastrin on mucus glycoprotein in rat gastric mucosal protection. Gastroenterol Jpn. 1992 Oct;27(5):597-603.

    [4]. A A Karelin,et al. Tetragastrin activation of rat gastric mucosa adenyl cyclase in vitro. Biull Eksp Biol Med. 1981 Apr;91(4):440-1.

Sincalide(Synonyms: Cholecystokinin octapeptide CCK-8 SQ19844)

发表于由

Sincalide;(Synonyms: Cholecystokinin octapeptide; CCK-8; SQ19844)

Sincalide (Cholecystokinin octapeptide) 是一种速效的胆囊收缩素 (CCK) 的氨基酸多肽激素类似物，可在胆囊造影术中静脉使用。Sincalide 是一种通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病的药物。Sincalide 的肝胆生理作用是增加胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而使胆汁排入十二指肠。

Sincalideamp;;(Synonyms: Cholecystokinin octapeptide; CCK-8; SQ19844)

Sincalide Chemical Structure

CAS No. : 25126-32-3

规格 价格 是否有货
1 mg ￥1100 询问价格 货期
5 mg ￥3000 询问价格 货期
10 mg ￥4800 询问价格 货期

* Please select Quantity before adding items.

Sincalide 的其他形式现货产品:

Sincalide ammonium

生物活性

Sincalide (Cholecystokinin octapeptide) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is an agent that promotes gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. The hepatobiliary physiologic effect of Sincalide ammonium is to increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum[1][2].

分子量

1143.27

Formula

C49H62N10O16S3
CAS 号

25126-32-3
Sequence Shortening

D-{SO3H-Tyr}-MGWMDF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

DMF : 50 mg/mL (43.73 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.09 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8747 mL 4.3734 mL 8.7468 mL
5 mM 0.1749 mL 0.8747 mL 1.7494 mL
10 mM 0.0875 mL 0.4373 mL 0.8747 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMF ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.19 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Maher KA et al. Kinevac (sincalide for injection)/Squibb Diagnostics. Gastroenterol Nurs. 1991 Oct;14(2):98-100.

    [2]. Ziessman HA. Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues. J Nucl Med Technol. 2019 Sep;47(3):210-212.

Cholecystokinin-33 品牌：Peptide

发表于由

Cholecystokinin-33

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

337-41761

 – 0.1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Cholecystokinin-33 品牌：Peptide

发表于由

Cholecystokinin-33

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-42011

 – 0.1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[Thr28,Nle31]-Cholecystokinin-33 (25-33) (sulflated) 品牌：Anygen

发表于由

[Thr28,Nle31]-Cholecystokinin-33 (25-33) (sulflated)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

304-92281

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Cholecystokinin (Non-sulfated Form) (Ammonium Form) 品牌：Peptide

发表于由

Cholecystokinin (Non-sulfated Form) (Ammonium Form)

品牌：Peptide
CAS No.：25679-24-7
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

336-40871

 – 0.5mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。