Ac-YVAD-CHO;(Synonyms: L-709049)
Ac-YVAD-CHO (L-709049) 是一种有效的、可逆的、特异性的四肽白介素 1β 转化酶 (ICE) 抑制剂，小鼠和人类 Ki 值分别为 3.0 和 0.76 nM。Ac-YVAD-CHO 可抑制成熟 IL-lβ 的产生。
Ac-YVAD-CHO Chemical Structure
CAS No. : 143313-51-3
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| 生物活性 |
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1]. |
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| IC50 Target |
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| 体外研究 (In Vitro) |
Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
492.52 |
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| Formula |
C23H32N4O8 |
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| CAS 号 |
143313-51-3 |
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| Sequence Shortening |
Ac-YVAD-CHO |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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