标签归档：cetrorelix

Cetrorelix diacetate(Synonyms: SB-75 diacetate)

发表于由

Cetrorelix diacetate;(Synonyms: SB-75 diacetate)

Cetrorelix diacetate (SB-075 diacetate)是 GnRH 受体的强效拮抗剂，其 IC50 值为 1.21 nM。

Cetrorelix diacetateamp;;(Synonyms: SB-75 diacetate)

Cetrorelix diacetate Chemical Structure

CAS No. : 130143-01-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Cetrorelix diacetate 的其他形式现货产品:

Cetrorelix Acetate

生物活性

Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM[1].

IC50 Target

IC50: 1.21 nM GnRH[1].
体外研究
(In Vitro)

Cetrorelix diacetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix diacetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1551.14

Formula

C74H100ClN17O18
CAS 号

130143-01-0
Sequence Shortening

Ac-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-SY-{Cit}-LRPA-NH2
中文名称

二醋酸西曲瑞克
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23.

    [2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.