标签归档：casomorphin

β-Casomorphin, bovine TFA(Synonyms: β-Casomorphin-7 (bovine) (TFA) Bovine β-casomorphin-7 TFA)

发表于由

β-Casomorphin, bovine TFA;(Synonyms: β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA)

β-casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) 是阿片 (opioid) 活性的多肽，与阿片受体结合的 IC50 值为 14 μM。

β-Casomorphin, bovine TFAamp;;(Synonyms: β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA)

β-Casomorphin, bovine TFA Chemical Structure

规格 价格 是否有货
5 mg ￥800 询问价格 货期
10 mg ￥1400 询问价格 货期
25 mg ￥2900 询问价格 货期

* Please select Quantity before adding items.

beta;-Casomorphin, bovine TFA 的其他形式现货产品:

beta;-Casomorphin, bovine

生物活性

β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].

IC50 Target

IC50: 14 μM (Opioid receptor)[1]
体外研究
(In Vitro)

β-Casomorphin, bovine TFA (0.1μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2].
β-Casomorphin, bovine TFA (0.1μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2].
β-Casomorphin, bovine TFA does not modify the expression of rMuc1, rMuc4, and rMuc5AC[2].
β-Casomorphin, bovine TFA (0.1μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley (SD) rats (200 g±10 g)[3]
Dosage: 7.5×10−6 mol/day/kg
Administration: Oral gavage; for 30 days
Result: Increased plasma insulin and decreased plasma glucagon of diabetic rats.

分子量

903.94

Formula

C43H56F3N7O11
Sequence

Tyr-Pro-Phe-Pro-Gly-Pro-Ile
Sequence Shortening

YPFPGPI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9.

    [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.

    [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.

β-Casomorphin (1-5), amide, bovine

发表于由

β-Casomorphin (1-5), amide, bovine;

β-Casomorphin (1-5), amide, bovine 是牛 β-Casomorphin 的多肽片段。

β-Casomorphin (1-5), amide, bovineamp;;

β-Casomorphin (1-5), amide, bovine Chemical Structure

CAS No. : 83936-23-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

β-Casomorphin (1-5), amide, bovine is a peptide of bovine β-Casomorphin.

分子量

626.77

Formula

C31H42N6O6S
CAS 号

83936-23-6
Sequence

Tyr-{d-Ala}-Phe-Pro-Met-NH2
Sequence Shortening

Y-{d-Ala}-FPM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

β-Casomorphin (1-6), bovine

发表于由

β-Casomorphin (1-6), bovine;

β-Casomorphin (1-6), bovine 是一种类阿片的 β-Casomorphin 生物活性肽片段。

β-Casomorphin (1-6), bovineamp;;

β-Casomorphin (1-6), bovine Chemical Structure

CAS No. : 77434-43-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

β-Casomorphin (1-6), bovine is a opioid-like bioactive peptide of β-Casomorphin.

分子量

676.76

Formula

C35H44N6O8
CAS 号

77434-43-6
Sequence Shortening

YPFPGP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chang WH, et al. β-Casomorphin increases fat deposition in broiler chickens by modulating expression of lipid metabolism genes. Animal. 2019 Apr;13(4):777-783.

β-Casomorphin (1-5), bovine

发表于由

β-Casomorphin (1-5), bovine;

β-Casomorphin (1-5), bovine 是牛 β-Casomorphin 的多肽片段。

β-Casomorphin (1-5), bovineamp;;

β-Casomorphin (1-5), bovine Chemical Structure

CAS No. : 72122-63-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

β-Casomorphin (1-5), bovine is a peptide of bovine β-Casomorphin.

分子量

579.64

Formula

C30H37N5O7
CAS 号

72122-63-5
Sequence

Tyr-Pro-Phe-Pro-Gly
Sequence Shortening

YPFPG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

β-Casomorphin (1-3), amide

发表于由

β-Casomorphin (1-3), amide;

β-Casomorphin (1-3), amide 是由 3 个氨基酸残基组成的 β-Casomorphin 的多肽片段。

β-Casomorphin (1-3), amideamp;;

β-Casomorphin (1-3), amide Chemical Structure

CAS No. : 80705-23-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

β-Casomorphin (1-3), amide is a peptide fragment of β-Casomorphin with 3 amino acid.

分子量

424.49

Formula

C23H28N4O4
CAS 号

80705-23-3
Sequence

Tyr-Pro-Phe-NH2
Sequence Shortening

YPF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

β-Casomorphin, human TFA(Synonyms: Human β-casomorphin 7 TFA)

发表于由

β-Casomorphin, human TFA;(Synonyms: Human β-casomorphin 7 TFA) 纯度: 99.67%

β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) 是一种阿片样肽，作为 opioid 受体激动剂。

β-Casomorphin, human TFAamp;;(Synonyms: Human β-casomorphin 7 TFA)

β-Casomorphin, human TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥1500 In-stock
10 mg ￥2500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

beta;-Casomorphin, human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Neurotransmitter Receptor Compound Library
  • Peptide Library

生物活性

β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor[1][2].

IC50 Target

Opioid receptor[2]
体外研究
(In Vitro)

β-Casomorphin, human TFA induces contractions of the guinea-pig ileum myenteric plexus/longitudinal muscle preparation with an IC50 of 29 μM[1].
β-Casomorphin, human TFA displaces 3H-spiperone from receptors in frontal cortex starting with 500 nM concentrations[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

978.02

Formula

C46H62F3N7O13
Sequence

Tyr-Pro-Phe-Val-Glu-Pro-Ile
Sequence Shortening

YPFVEPI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (102.25 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0225 mL 5.1124 mL 10.2247 mL
5 mM 0.2045 mL 1.0225 mL 2.0449 mL
10 mM 0.1022 mL 0.5112 mL 1.0225 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (2.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.56 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Brantl V. Novel opioid peptides derived from human beta-casein: human beta-casomorphins. Eur J Pharmacol. 1984 Oct 30;106(1):213-4.

    [2]. Koch G, et al. Opioid activities of human beta-casomorphins. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):351-4.

β-Casomorphin-5 (Bovine) 品牌：Peptide

发表于由

β-Casomorphin-5 (Bovine)

品牌：Peptide
CAS No.：72122-63-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

338-40794

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