标签归档：carotene

β-Carotene(Synonyms: β-胡萝卜素; Provitamin A; beta-Carotene)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

β-Carotene (Synonyms: β-胡萝卜素; Provitamin A; beta-Carotene) 纯度: ≥98.0%

β-Carotene (Provitamin A) 属于类胡萝卜素化合物，是天然存在的维生素 A 前体。β-Carotene 是一种 ROS 调节剂，具有抗氧化和抗炎活性。β-Carotene 可作为抗氧化剂或者促氧化剂，取决于它的内在特性以及它所作用的生物环境的氧化还原电位。 β-Carotene 可诱导乳腺癌细胞凋亡 (apoptosis)，具有抗癌活性。

β-Carotene(Synonyms: β-胡萝卜素; Provitamin A; beta-Carotene)

β-Carotene Chemical Structure

CAS No. : 7235-40-7

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β-Carotene 相关产品

•相关化合物库:

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生物活性

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities[1][2][3][4][5].

IC50 & Target[3]

Human Endogenous Metabolite

 

ROS

 

apoptosis

 

体外研究
(In Vitro)

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells[3].
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner[3].
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner[3].
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner[3].
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187)[3].
β-Carotene induces cytochrome C release[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[5]

Cell Line: MCF-7 cells
Concentration: 1 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time: 72 hours
Result: Decreased the numbers of viable cells to 70% and 50% at 20 μM and 50 μM, respectively.

RT-PCR[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated the PPAR-γ mRNA.

Western Blot Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated PPAR-γ protein expression levels.

Apoptosis Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 72 hours
Result: Induced MCF-7 cells apoptosis.

Clinical Trial

分子量

536.87

Formula

C40H56
CAS 号

7235-40-7
中文名称

β-胡萝卜素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro: 

THF : 20 mg/mL (37.25 mM; Need ultrasonic)

Acetone : 5 mg/mL (9.31 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6265 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
10 mM 0.1863 mL 0.9313 mL 1.8626 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tanumihardjo, S.A., Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res, 2002. 72(1): p. 40-5.

    [2]. Leo, M.A., et al. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr, 1999. 69(6): p. 1071-85.

    [3]. Yanhong Cui, et al. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer. 2007 Nov;43(17):2590-601.

    [4]. AKIFUMI KAWATA, et al. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr; 32(2): 255-264.

    [5]. Paola Palozza, et al. Prooxidant effects of beta-carotene in cultured cells. Mol Aspects Med. 2003 Dec;24(6):353-62.