标签归档：calcineurin

Calcineurin substrate(Synonyms: 钙调神经磷酸酶底物)

发表于由

Calcineurin substrate;(Synonyms: 钙调神经磷酸酶底物)

Calcineurin substrate 是来自 cAMP 依赖性蛋白激酶调节性 RII 亚基的多肽。Calcineurin substrate 可用于钙调神经磷酸酶活力的测定。

Calcineurin substrateamp;;(Synonyms: 钙调神经磷酸酶底物)

Calcineurin substrate Chemical Structure

CAS No. : 113873-67-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Calcineurin substrate 的其他形式现货产品:

Calcineurin substrate TFA

生物活性

Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. It can be used in the calcineurin activity assay.

体外研究
(In Vitro)

Calcineurin (PP2B), a serine/threonine phosphatase controlled by cellular calcium, has been implicated in a wide variety of biological responses including lymphocyte activation, neuronal and muscle development, neurite outgrowth, and morphogenesis of vertebrate heart valves[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2112.35

Formula

C92H150N28O29
CAS 号

113873-67-9
Sequence

Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu
Sequence Shortening

DLDVPIPGRFDRRVSVAAE
中文名称

钙调神经磷酸酶底物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Crabtree GR, et al. Calcium, calcineurin, and the control of transcription. J Biol Chem. 2001 Jan 26;276(4):2313-6.

Calcineurin autoinhibitory peptide TFA

发表于由

Calcineurin autoinhibitory peptide TFA;

Calcineurin autoinhibitory peptide TFA 是一种选择性的 Ca2+/ 钙调蛋白依赖性蛋白磷酸酶(钙调神经磷酸酶)的抑制剂，IC50 值大约为 10 μM。Calcineurin autoinhibitory peptide TFA 可以保护神经元免受兴奋性神经元死亡。

Calcineurin autoinhibitory peptide TFAamp;;

Calcineurin autoinhibitory peptide TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Calcineurin autoinhibitory peptide TFA 的其他形式现货产品:

Calcineurin autoinhibitory peptide

生物活性

Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death[1][2].

IC50 Target

IC50: ~10 μM (calcineurin)[1]
分子量

3044.34

Formula

C126H206F3N39O41S2
Sequence Shortening

ITSFEEAKGLDRINERMPPRRDAMP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7.

    [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.

Calcineurin substrate TFA

发表于由

Calcineurin substrate TFA; 纯度: 99.57%

Calcineurin substrate (TFA) 是来自 cAMP 依赖性蛋白激酶调节性RII亚基的多肽。Calcineurin substrate (TFA) 可用于钙调神经磷酸酶活力的测定。

Calcineurin substrate TFAamp;;

Calcineurin substrate TFA Chemical Structure

规格 价格 是否有货 数量
500 μg ￥1100 In-stock
1 mg ￥1950 In-stock
5 mg ￥8400 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Calcineurin substrate TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Calcineurin substrate (TFA) is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate (TFA) can be used in the calcineurin activity assay[1].

分子量

2226.37

Formula

C94H151F3N28O31
Sequence

Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu
Sequence Shortening

DLDVPIPGRFDRRVSVAAE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Crabtree GR, et al. Calcium, calcineurin, and the control of transcription. J Biol Chem. 2001 Jan 26;276(4):2313-6.

Calcineurin autoinhibitory peptide

发表于由

Calcineurin autoinhibitory peptide; 纯度: 99.71%

Calcineurin autoinhibitory peptide 是一种选择性的 Ca2+/ 钙调蛋白依赖性蛋白磷酸酶(钙调神经磷酸酶)的抑制剂，IC50 值大约为 10 μM。Calcineurin autoinhibitory peptide 可以保护神经元免受兴奋性神经元死亡。

Calcineurin autoinhibitory peptideamp;;

Calcineurin autoinhibitory peptide Chemical Structure

CAS No. : 148067-21-4

规格 价格 是否有货 数量
1 mg ￥2100 In-stock
5 mg ￥4800 In-stock
10 mg ￥7600 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Calcineurin autoinhibitory peptide 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].

IC50 Target

IC50: ~10 μM (calcineurin)[1]
分子量

2930.32

Formula

C124H205N39O39S2
CAS 号

148067-21-4
Sequence Shortening

ITSFEEAKGLDRINERMPPRRDAMP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (34.13 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3413 mL 1.7063 mL 3.4126 mL
5 mM 0.0683 mL 0.3413 mL 0.6825 mL
10 mM 0.0341 mL 0.1706 mL 0.3413 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7.

    [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.