天然产物 糖类和糖苷 Saccharides and Glycosides
Bleomycin sulfate;(Synonyms: 硫酸博来霉素) 纯度: 99.60%
Bleomycin sulfate 是一种 DNA 损伤剂,抑制 DNA 合成。Bleomycin sulfate 是一种抗肿瘤抗生素 (antibiotic)。
Bleomycin sulfate Chemical Structure
CAS No. : 9041-93-4
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10;mM;*;1 mL in DMSO | ¥2166 | In-stock | |
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Bleomycin sulfate 相关产品
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生物活性 |
Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic[1]. |
IC50 Target |
DNA/RNA Synthesis[1] |
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体外研究 (In Vitro) |
Bleomycin (BLM) sulfate is chosen as the best-studied micronucleus (MN) inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Bleomycin sulfate treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
1512.62 |
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Formula |
C55H85N17O25S4 |
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CAS 号 |
9041-93-4 |
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中文名称 |
硫酸博来霉素;硫酸博莱霉素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4deg;C, sealed storage, away from moisture *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
H2O : 255 mg/mL (168.58 mM; Need ultrasonic and warming) DMSO : 62.5 mg/mL (41.32 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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