标签归档：bcl

Restriction Endonuclease Bcl I 品牌：Nippon Gene

发表于由

Restriction Endonuclease Bcl I

品牌：Nippon Gene
CAS No.：81295-11-6
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

312-02514

 – 400U×10 – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Anti-BCL6, Human, Rabbit-Poly 品牌：Protein Exp

发表于由

Anti-BCL6, Human, Rabbit-Poly

品牌：Protein Exp
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

KB4594GNPAF

 – 50 ug – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Restriction Endonuclease Bcl I 品牌：Nippon Gene

发表于由

Restriction Endonuclease Bcl I

品牌：Nippon Gene
CAS No.：81295-11-6
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

318-02511

 – 400U – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

F1324 acetate

发表于由

F1324 acetate;

F1324 acetate 是一种有效、高亲和力的 BCL6 多肽抑制剂，IC50 值为 1 nM。F1324 acetate 结合 BCL6 动力学 t1/2 为 441 s, 对 BCL6 PPI 具有很强的抑制作用。

F1324 acetateamp;;

F1324 acetate Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

F1324 acetate is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. F1324 acetate exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI[1].

IC50 Target

IC50: 1 nM (BCL6)[1]
体外研究
(In Vitro)

F1324 acetate binds to BCL6(5-129) with KD and IC50 values of 0.57 nM and 1 nM according to the results of an SPR analysis and cell-free ELISA assay, respectively[1].
F1324 acetate binds BCL6 not only in cell-free but also cellbased conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1825.09

Formula

C2H4O2
Sequence Shortening

Ac-LWYTDIRMSWRVP-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sakamoto K, et al. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem Biophys Res Commun. 2017 Jan 8;482(2):310-316.

BH3 hydrochloride

发表于由

BH3 hydrochloride;

BH3 hydrochloride 是能透过血脑屏障的多肽，通过直接激活促凋亡 Bax/Bak 或通过中和抗凋亡 Bcl-2 蛋白 (Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)来诱导细胞凋亡，通过与BH3 结构域结合。

BH3 hydrochlorideamp;;

BH3 hydrochloride Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian[1][2].

分子量

2677.45

Formula

C120H183ClN36O32
Sequence

Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
Sequence Shortening

IWIAQELRRIGDEFNAYYARR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Guang Yang, et al. Modulating Protein-Protein Interactions In Vivo via Peptide-Lanthanide-Derived Nanoparticles for Hazard-Free Cancer Therapy. J Biomed Nanotechnol. 2019 Sep 1;15(9):1937-1947.

    [2]. Shatrunajay Shukla, et al. BH3-only Protein BIM: An Emerging Target in Chemotherapy. Eur J Cell Biol. 2017 Dec;96(8):728-738.

F1324 TFA

发表于由

F1324 TFA;

F1324 TFA 是一种有效、高亲和力的 BCL6 多肽抑制剂，IC50 值为 1 nM。F1324 TFA 结合 BCL6 动力学 t1/2 为 441 s, 对 BCL6 PPI 具有很强的抑制作用。

F1324 TFAamp;;

F1324 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. F1324 TFA exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI[1].

IC50 Target

IC50: 1 nM (BCL6)[1]
体外研究
(In Vitro)

F1324 TFA binds to BCL6(5-129) with KD and IC50 values of 0.57 nM and 1 nM according to the results of an SPR analysis and cell-free ELISA assay, respectively[1].
F1324 TFA binds BCL6 not only in cell-free but also cellbased conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1879.06

Formula

C85H122N21F3O22S
Sequence Shortening

Ac-LWYTDIRMSWRVP-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sakamoto K, et al. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem Biophys Res Commun. 2017 Jan 8;482(2):310-316.

Bak BH3

发表于由

Bak BH3;

Bak BH3 是一种多肽，源于 Bak 蛋白的 BH3 结构域，在细胞中，能够抑制 Bcl-xL 的活性。

Bak BH3amp;;

Bak BH3 Chemical Structure

规格 价格 是否有货
1 mg ￥1100 询问价格 货期
5 mg ￥3300 询问价格 货期
10 mg ￥5500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

IC50 Target[1]

Bcl-xL

;

体外研究
(In Vitro)

Bak BH3 peptide antagonize the protective effects of microinjected Bcl-xL in α-Fas-treated HeLa cells, whereas a mutant Bak BH3 peptide that no longer binds Bcl-xL is inactive[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1724.90

Formula

C72H125N25O24
Sequence

Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg
Sequence Shortening

GQVGRQLAIIGDDINR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Holinger EP, et al. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 7;274(19):13298-304.
Cell Assay
[1]

Cells are plated in complete DMEM in 96-well tissue culture plates at 4×103/well. After 24 h, cells are washed with PBS and treated with peptides (50 μM) in SF-DMEM. Cell viability is determined by staining unfixed cells with calcein AM/ethidium homodimer, followed by microscopic analysis of cell staining and cellular morphology on a Nikon Diaphot 300 inverted microscope equipped with a fluorescence module.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Holinger EP, et al. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 7;274(19):13298-304.

Bcl6 monoclonal antibody (SPM602) Bcl6 单克隆抗体 (SPM602) 品牌：Enzo

发表于由

Bcl6 monoclonal antibody (SPM602)

Bcl6 单克隆抗体 (SPM602)

品牌：Enzo
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

ENZ-ABS771-0100

 – 100 µg – 10,210.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Restriction Endonuclease Bcl I 品牌：Nippon Gene

发表于由

Restriction Endonuclease Bcl I

品牌：Nippon Gene
CAS No.：81295-11-6
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

314-02513

 – 400U×5 – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

anti-Bcl-2, mAb (2B11) 抗Bcl-2，单克隆抗体（2B11） 品牌：AbFrontier

发表于由

anti-Bcl-2, mAb (2B11)

抗Bcl-2，单克隆抗体（2B11）

品牌：AbFrontier
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

YIF-LF-MA0199

 – 100 ul –

anti-Bcl-2, mAb (2B11) 抗Bcl-2，单克隆抗体（2B11） 品牌：AbFrontier

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。