天然产物 糖类和糖苷 Saccharides and Glycosides
Baicalin;(Synonyms: 黄芩苷; Baicalein 7-O-β-D-glucuronide) 纯度: 99.17%
Baicalin 作为一种类黄酮糖苷,是一种变构肉碱棕榈酰转移酶1 (CPT1)是激活剂。Baicalin 降低 NF-κB 表达。
Baicalin Chemical Structure
CAS No. : 21967-41-9
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | ; | Apply now | ; |
10;mM;*;1 mL in DMSO | ¥500 | In-stock | |
10 mg | ¥390 | In-stock | |
50 mg | ¥700 | In-stock | |
100 mg | ¥900 | In-stock | |
500 mg | ¥1200 | In-stock | |
1 g | ¥2100 | In-stock | |
5 g | ¥5000 | In-stock | |
10 g | ; | 询价 | ; |
50 g | ; | 询价 | ; |
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Baicalin 相关产品
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生物活性 |
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[1][2][3]. |
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IC50 Target[1] |
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体外研究 (In Vitro) |
Baicalin protects against ischemia-reperfusion injury (IRI) by altering the production of various mediators, including reactive oxygen species (ROS), Toll-like receptor (TLR)2 and TLR4, NF-κB, Bax, and Bcl-2. Baicalin treatment inhibits the increased expression of the proinflammatory cytokines TLR2/4, MyD88, p-NF-κB, and p- IκB, as well as increase the expression of IκB protein, an NF-κB inhibitor, with the degree of inhibition positively related to the dosage of Baicalin[1]. Cell viability is determined by MTT assay. Compared with control cells, cell viability is significantly decreased in SH-SY5Y cells treated with thrombin. Pre-treatment with Baicalin (5, 10, 20 μM) increases cell viability in a dose-dependent manner compared with cells treated thrombin alone[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Baicalin pretreatment dose-dependently protects against a loss of renal function, with the two higher doses (10 and 100 mg/kg) significantly decreasing Scr and blood urea nitrogen (BUN) concentrations. Tissue injury, as assessed using a 0-3 point scoring system, is lower for the Baicalin treated groups than for the ischemia-reperfusion (IR)+saline group. Compared with the sham group, malondialdehyde (MDA) content is only slightly up-regulated and the SOD activity is only slightly down-regulated in rats treated with 10 and 100 mg/kg Baicalin, indicating that Baicalin abrogates the increase in oxidative stress following reperfusion[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
446.36 |
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Formula |
C21H18O11 |
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CAS 号 |
21967-41-9 |
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中文名称 |
黄芩苷 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 100 mg/mL (224.03 mM) H2O : 0.1 mg/mL (0.22 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [2] |
SH-SY5Y cell lines are cultured in RPMI-1640 medium supplemented with 15% fetal bovine serum at 37°C in an air atmosphere containing 95% air and 5% CO2 with a saturated humidity. Upon a confluence of 60~70%, the SH-SY5Y cells are divided into: (i) control group, incubated in RPMI-1640 medium; (ii) thrombin group, which is subject to thrombin induction (40 U/L) for 6 h based on our pre-experiment; and (iii) Baicalin groups, which are treated by Baicalin (5 μM, 10 μM, or 20 μM) for 2 h before induction of thrombin. Cell viability is measured using MTT assay. Briefly, 15 μL of the MTT solution (5 mg/mL) is added to each well and incubated for 4 h at 37°C. After removing the supernatant, 80 μL DMSO are added into each well. The absorbance is measured at 492 nm using a microplate reader. All experiments are performed in triplicate[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
Rats[1] MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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