标签归档：aunp

AUNP-12 TFA(Synonyms: NP-12 TFA)

发表于由

AUNP-12 TFA;(Synonyms: NP-12 TFA) 纯度: ge;96.0%

AUNP-12 (NP-12) TFA 是 PD-1 信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。AUNP-12 TFA 具有免疫激活作用、良好的抗肿瘤活性，具有更好的研究免疫相关不良事件 (irAEs) 的潜力。

AUNP-12 TFAamp;;(Synonyms: NP-12 TFA)

AUNP-12 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1300 In-stock
5 mg ￥3400 In-stock
10 mg ￥5600 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

AUNP-12 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].

IC50 Target

PD-1 signaling pathway[1]
体外研究
(In Vitro)

NP-12 TFA displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1].
NP-12 TFA rescues the proliferation in the mouse splenocyte assay system with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively [1].
NP-12 TFA is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3375.57

Formula

C5H17TFIN2O2S2Si
Sequence Shortening

H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18(6):1081-1091.

AUNP-12(Synonyms: NP-12)

发表于由

AUNP-12;(Synonyms: NP-12)

AUNP-12 (NP-12) 是 PD-1 信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。AUNP-12 具有免疫激活作用、良好的抗肿瘤活性，具有更好的研究免疫相关不良事件 (irAEs) 的潜力。

AUNP-12amp;;(Synonyms: NP-12)

AUNP-12 Chemical Structure

CAS No. : 1353563-85-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

AUNP-12 的其他形式现货产品:

AUNP-12 TFA

生物活性

AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].

IC50 Target

PD-1 signaling pathway[1]
体外研究
(In Vitro)

AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1].
AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1].
AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3261.55

Formula

C5H17TFIN2O2S2Si
CAS 号

1353563-85-5
Sequence Shortening

H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18(6):1081-1091.