Apraglutide TFA(Synonyms: FE 203799 TFA)

发表于2024年4月15日由Whatman官网

Apraglutide TFA;(Synonyms: FE 203799 TFA) 纯度: 98.18%

Apraglutide TFA (FE 203799 TFA) 是一种合成的33-氨基酸肽和长效的 GLP-2类似物，能够增强全回肠切除的新生短肠综合征小猪的适应性和线性肠生长。

Apraglutide TFAamp;;(Synonyms: FE 203799 TFA)

Apraglutide TFA Chemical Structure

规格	价格	是否有货	数量
1 mg	￥1200	In-stock
5 mg	￥3300	In-stock
10 mg	￥5200	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum^[1].

体内研究
(In Vivo)

Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NewbornDuroc piglets, 2-5 days old and weighing between 2-2.6 kg^[1].
Dosage:	5 mg/kg/dose.
Administration:	Subcutaneously, twice on days 0 and 4 postsurgery.
Result:	On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.

Clinical Trial

分子量

3879.27

Formula

C₁₇₂H₂₆₃N₄₃O₅₂.C₂HF₃O₂

Sequence

His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Nle-D-Phe-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH2

Sequence Shortening

HGDGSFSDEX FTILDLLAAR DFINWLIQTK ITD-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Slim GM, et al. Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum. JPEN J Parenter Enteral Nutr. 2019 Jan 6.

Apraglutide(Synonyms: FE 203799)

发表于2024年3月24日由Whatman官网

Apraglutide;(Synonyms: FE 203799) 纯度: 98.45%

Apraglutide (FE 203799) 是一种合成的33-氨基酸肽和长效的 GLP-2类似物，能够增强全回肠切除的新生短肠综合征小猪的适应性和线性肠生长。

Apraglutide Chemical Structure

CAS No. : 1295353-98-8

规格	价格	是否有货	数量
1 mg	￥1200	In-stock
5 mg	￥3300	In-stock
10 mg	￥5200	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Apraglutide 相关产品

bull;相关化合物库:

Drug Repurposing Compound Library Plus
Clinical Compound Library Plus
Bioactive Compound Library Plus
Peptide Library

生物活性

Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum^[1].

体内研究
(In Vivo)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg^[1].
Dosage:	5 mg/kg/dose.
Administration:	Subcutaneously, twice on days 0 and 4 postsurgery.
Result:	On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.

Clinical Trial

分子量

3765.25

Formula

C₁₇₂H₂₆₃N₄₃O₅₂

CAS 号

1295353-98-8