MAIT-203;
MAIT-203 是一种环戊丙氨酸衍生的拟肽，有效抑制腺瘤性息肉病 (APC) 和 Asef (RhoGEF4) 的相互作用，但不抑制 APC-Sam68 或 APC-striatin 的相互作用。MAIT-203 结合 APC-ARM，Ki 值为 0.015 μM，Kd 值为 0.036 μM。MAIT-203 显着抑制结直肠癌细胞的迁移和侵袭。
MAIT-203 Chemical Structure
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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| 生物活性 |
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells. |
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| 体外研究 (In Vitro) |
MAIT-203 (10 μM and 25 μM; for 24 h) reduces Asef-APC interaction in a dose-dependent manner in HEK293T cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
2517.85 |
| Formula |
C106H177N43O29 |
| Sequence Shortening |
Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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