A 71915;
A 71915 是一种具有高效、竞争性的 natriuretic peptide receptor A (ANP, NPRA) 拮抗剂 (pKi= 9.18). A71915 的剂量依赖性取代 [125I]ANP，Ki为0.65 nM。A71915 (pA2= 9.48) 对大鼠 ANP 诱导的 NB-OK-1 细胞产生 cGMP 的作用。
A 71915 Chemical Structure
CAS No. : 132956-87-7
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| 生物活性 |
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1]. |
IC50 Target |
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist, with a pKi of 9.18. |
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| 体外研究 (In Vitro) |
A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching[2]. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
1613.95 |
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| Formula |
C69H116N26O15S2 |
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| CAS 号 |
132956-87-7 |
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| Sequence |
Arg-Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13) |
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| Sequence Shortening |
{RC-Cha}-GGRIDRI-{D-Tic-RC}-NH2 (Disulfide bridge: Cys2-Cys13) |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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