标签归档：aktide

AKTide-2T TFA

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AKTide-2T TFA;

AKTide-2T TFA 是一个优良的体外 AKT 底物，可竞争性抑制组蛋白 H2B 磷酸化，其 Ki 值为 12 nM。AKTide-2T TFA 模拟 Akt 的最佳磷酸化序列，是一种抑制肽，是 S22 位置中缺失了野生型 AKTide。

AKTide-2T TFAamp;;

AKTide-2T TFA Chemical Structure

规格 是否有货
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生物活性

AKTide-2T TFA is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].

IC50 Target[1]

Akt

;

体外研究
(In Vitro)

AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1829.89

Formula

C76H115F3N28O22
Sequence

Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala
Sequence Shortening

ARKRERTYSFGHHA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15.

    [2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35.