Darutoside

天然产物 糖类和糖苷 Saccharides and Glycosides

Darutoside;

Darutoside 是从Siegesbeckia 中提取得到的一种二萜化合物。

Darutoside

Darutoside Chemical Structure

CAS No. : 59219-65-7

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生物活性

Darutoside is a diterpenoid isolated from Siegesbeckia[1].

分子量

484.62

Formula

C26H44O8

CAS 号

59219-65-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kim, J.H. Han, et al. Darutoside, a diterpenoid from Siegesbeckia pubescens and its structure revision. Food and Agriculture Organization of the United Nations. 1979.

Polygalasaponin V(Synonyms: 瓜子金皂苷 V)

天然产物 糖类和糖苷 Saccharides and Glycosides

Polygalasaponin V;(Synonyms: 瓜子金皂苷 V)

Polygalasaponin V 是一种从 Polygala japonica 的地上部分分离的三萜皂苷。Polygala japonica 是一种民间药用植物,在中国南方用作祛痰,抗炎,抗菌和抗抑郁药。

Polygalasaponin V(Synonyms: 瓜子金皂苷 V)

Polygalasaponin V Chemical Structure

CAS No. : 162857-65-0

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Polygalasaponin V 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Glycoside Compound Library
  • Terpenoids Library

生物活性

Polygalasaponin V is a triterpenoid saponin isolated from the aerial parts of Polygala japonica. Polygala japonica has been a folk medicine herb used as expectorant, anti-inflammatory, antibacterial and antidepressant agents in the south of China[1].

分子量

1223.35

Formula

C58H94O27

CAS 号

162857-65-0

中文名称

瓜子金皂苷 V

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (81.74 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8174 mL 4.0871 mL 8.1743 mL
5 mM 0.1635 mL 0.8174 mL 1.6349 mL
10 mM 0.0817 mL 0.4087 mL 0.8174 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (2.04 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.04 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.04 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.04 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.04 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.04 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Li TZ , et al. Saponins from Polygala japonica and their effects on a forced swimming test in mice. J Nat Prod. 2006 Apr;69(4):591-4.

Glucosinalbate

天然产物 糖类和糖苷 Saccharides and Glycosides

Glucosinalbate;

Glucosinalbate 是从拟南芥中分离得到的一种天然产物。

Glucosinalbate

Glucosinalbate Chemical Structure

CAS No. : 19253-84-0

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生物活性

Glucosinalbate is a natural product that can be isolated from Arabidopsis thaliana[1].

分子量

423.46

Formula

C15H21NO9S2

CAS 号

19253-84-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Muto-Fujita A, et al. Data integration aids understanding of butterfly-host plant networks. Sci Rep. 2017 Mar 6;7:43368.

Retrobradykinin

Retrobradykinin;

Retrobradykinin 的序列与缓激肽相反(HY-P0206)。Retrobradykinin 没有激肽活性,可作为缓激肽的阴性对照。

Retrobradykininamp;;

Retrobradykinin Chemical Structure

CAS No. : 5991-13-9

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生物活性

Retrobradykinin has the reverse sequence of Bradykinin (HY-P0206). Retrobradykinin exhibits no kinin activity and can be used as a negative control for Bradykinin[1].

分子量

1060.21

Formula

C50H73N15O11

CAS 号

5991-13-9

Sequence

Arg-Phe-Pro-Ser-Phe-Gly-Pro-Pro-Arg

Sequence Shortening

RFPSFGPPR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Saul Lande, et al. Retrobradykinin: a Peptide with the Reverse Sequence of Bradykinin. J. Org. Chem. 1962, 27, 12, 4558–4562

(E)-Coniferin(Synonyms: (E)-Laricin)

天然产物 糖类和糖苷 Saccharides and Glycosides

(E)-Coniferin;(Synonyms: (E)-Laricin)

(E)-Coniferin 是Coniferin 的一种异构体。Coniferin (Laricin) 是松柏醇的一种葡萄糖苷。Coniferin 抑制真菌生长和黑化反应。

(E)-Coniferin(Synonyms: (E)-Laricin)

(E)-Coniferin Chemical Structure

CAS No. : 124151-33-3

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50 mg ¥14500 询问价格 货期

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生物活性

(E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization[1].

分子量

342.34

Formula

C16H22O8

CAS 号

124151-33-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. König S, et al. Soluble phenylpropanoids are involved in the defense response of Arabidopsis against Verticillium longisporum. New Phytol. 2014 May;202(3):823-37.

N-Acetyloxytocin

N-Acetyloxytocin;

N-Acetyloxytocin 是在大鼠垂体神经中间叶 (NIL) 中分离出来的,其存在于大鼠的几个脑区。

N-Acetyloxytocinamp;;

N-Acetyloxytocin Chemical Structure

CAS No. : 10551-48-1

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生物活性

N-Acetyloxytocin is isolated and characterized in the neurointermediate lobe of the rat pituitary (NIL) and their presence in several brain areas of the rat[1].

体外研究
(In Vitro)

N-Acetyloxytocin is a post-translational modification of vasopressin (VP), and oxytocin (OT). The acetylated forms arc not restricted to the pineal gland, the tissue in which N-Acetyloxytocin is initially identified, but also occur in other systems producing OT and VP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1049.22

Formula

C45H68N12O13S2

CAS 号

10551-48-1

Sequence Shortening

Ac-CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Liu B, et al. N-acetyl-vasopressin- and N-acetyl-oxytocin-like substances: isolation and characterization in the rat neurointermediate pituitary and presence in the brain. J Neuroendocrinol. 1989;1(1):47-52.

Cortagine

Cortagine;

Cortagine 是一种选择性的促肾上腺皮质激素释放因子受体亚型 1 (CRF1) 激动剂,对 rCRF1 的 IC50 为 2.6 nM。Cortagine 在小鼠模型中具有抗焦虑和抗抑郁作用。

Cortagineamp;;

Cortagine Chemical Structure

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生物活性

Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model[1].

IC50 Target

IC50: 2.6 nM (rCRF1)[1]

体外研究
(In Vitro)

Cortagine inhibits rCRF1 (EC50=0.18 nM) and mCRF (EC50=16 nM) in transfected HEK-293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4442.06

Formula

C192H323N55O63S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hossein Tezval, et al. Cortagine, a Specific Agonist of Corticotropin-Releasing Factor Receptor Subtype 1, Is Anxiogenic and Antidepressive in the Mouse Model. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9468-73.

C-telopeptide

C-telopeptide;

C-telopeptide 是一种 I 型胶原蛋白的交联肽,在骨吸收过程中释放,并与骨矿物质密度 (BMD) 相关。

C-telopeptideamp;;

C-telopeptide Chemical Structure

CAS No. : 162929-64-8

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生物活性

C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

体外研究
(In Vitro)

C-telopeptide (C-terminal telopeptide of type 1 collagen, CTx)-a marker for bone resorption. It is a peptide fragment from the carboxy terminal end of the protein matrix; used to monitor anti-resorptive therapies, such as bisphosphonates and hormone replacement therapy, in postmenopausal women and people with low bone mass (osteopenia)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

868.90

Formula

C34H56N14O13

CAS 号

162929-64-8

Sequence

Glu-Lys-Ala-His-Asp-Gly-Gly-Arg

Sequence Shortening

EKAHDGGR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Bradykinin (1-3)

Bradykinin (1-3);

Bradykinin (1-3) 是一个含 3个氨基酸的残基肽。Bradykinin (1-3) 是由脯氨酰内肽酶切割形成的一种氨基截短的激肽肽。

Bradykinin (1-3)amp;;

Bradykinin (1-3) Chemical Structure

CAS No. : 23815-91-0

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生物活性

Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

分子量

368.43

Formula

C16H28N6O4

CAS 号

23815-91-0

Sequence

Arg-Pro-Pro

Sequence Shortening

RPP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Asp-Asp-Asp-Asp-Asp

Asp-Asp-Asp-Asp-Asp;

Asp-Asp-Asp-Asp-Asp 是由 5 个天冬氨酸残基组成的多肽。

Asp-Asp-Asp-Asp-Aspamp;;

Asp-Asp-Asp-Asp-Asp Chemical Structure

CAS No. : 124219-00-7

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生物活性

Asp-Asp-Asp-Asp-Asp is a peptide consists of 5 Asp.

分子量

593.45

Formula

C20H27N5O16

CAS 号

124219-00-7

Sequence

Asp-Asp-Asp-Asp-Asp

Sequence Shortening

DDDDD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.