Hexa-N-acetylchitohexaose

天然产物 糖类和糖苷 Saccharides and Glycosides

Hexa-N-acetylchitohexaose;

Hexa-N-acetylchitohexaose 是作物抗病性的诱导剂,可诱导大豆木质化相关酶和抗氧化酶活性的增加。Hexa-N-acetylchitohexaose 是溶菌酶的底物。Hexa-N-acetylchitohexaose 具有抗肿瘤作用。

Hexa-N-acetylchitohexaose

Hexa-N-acetylchitohexaose Chemical Structure

CAS No. : 38854-46-5

规格 价格 是否有货
1 mg ¥2200 询问价格 货期

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生物活性

Hexa-N-acetylchitohexaose is an inducer of disease resistance in crop plants, which could elicit an increase of lignification-related and antioxidative enzymes in soybean plants. Hexa-N-acetylchitohexaose is a substrate of lysozyme. Hexa-N-acetylchitohexaose shows antitumor effect[1][2][3].

体内研究
(In Vivo)

On sarcoma 180 solid tumor in ddY mice using lentinan, an antitumorβ-D-glucan, as the positive control. Hexa-N-acetylchitohexaose (100 mg/kg/day; 3 times; intravenous ) significantly inhibits the growth of this allogenic solid tumor, affording a high tumor growth-inhibition ratio (85%) at 7 days after tumor implantation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1237.17

Formula

C48H80N6O31

CAS 号

38854-46-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li K, et al. Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation. Biomed Res Int. 2017;2017:2486515.

    [2]. David C. Phillips. THE HEN EGG-WHITE LYSOZYME MOLECULE. Proc Natl Acad Sci U S A. 1967 Mar; 57(3): 483-495.

    [3]. Suzuki K, et al. Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose. Carbohydr Res. 1986;151:403-408.

变异诱导剂等

变异诱导剂等

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  • 相关资料
  • Q&A
  • 参考文献

变异诱导剂等变异诱导剂等



解析与表现型和遗传因子项链接的突变体,是识别遗传因子的有效方法。

Ethyl Methanesulfonate(EMS)是诱变DNA醇化的烷化剂。

Colchicine 是使染色体加倍从而使染色体变异的化合物。

产品列表
产品编号 产品名称 产品规格 产品等级 备注
039-03851 Colchicine  ≧95.0%
 秋水仙素
100 mg 和光一级
035-03853 Ethyl Methanesulfonate
 甲磺酸乙酯
1 g 和光一级
325-81522 Ethyl Methanesulfonate
 甲磺酸乙酯
25 g Wako
323-81523 Ethyl Methanesulfonate
 甲磺酸乙酯
100 g Wako

Biostir® 特应性皮炎诱导剂AD Biostir® AD

 Biostir® 特应性皮炎诱导剂AD

 

产品编号 产品名称 中文名称 包装 备注
309-34133 Biostir® AD Biostir® 特应性皮炎诱导剂AD 5 g 软膏包括来自粉尘螨的螨过敏原,-30℃
303-34131 Biostir® AD Biostir® 特应性皮炎诱导剂AD 15 g
项目 方法 动物
特应性皮炎模型服务和药理学测试  1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir® AD

诱导特应性皮炎样损伤。

2. 经皮致敏/免疫小鼠。

3. 高概率获得特应性皮炎模型。

4. 评估测试物质对疾病模型的效力。

5. 评价项目:症状评分,IgE,组织病理学,搔抓行为等。

小鼠
(NC/Nga)

 

◆特征

● 是特应性皮炎相关的房尘螨提取物成分之一

● Biostir® AD能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤

● 在该模型中观察到他克莫司软膏和皮质类固醇软膏的功效

● Biostir® AD能高概率在NC/Nga小鼠引起皮炎

● Biostir® AD节省时间和精力,与重复应用螨过敏原悬浮液相比较直到观察到皮炎发病

● 现今还没有类似概念的产品

 

◆操作流程

用 4% 十二烷基硫酸钠(SDS)破坏屏障后,每周两次在剃毛的背部皮肤和两耳廓部涂抹100 mg的AD。
重复此步骤3周。共涂抹6次完成。

 

◆应用实例

 

动物 雌性NC / Nga小鼠
 

特应性皮炎样皮肤损伤的临床方面

 

 

在皮肤上观察到搔抓行为,红斑,丘疹,鳞屑,疮痂和苔藓病变

 

组织学评价 损伤皮肤表现在真皮和表皮显著增厚,角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。
 

血清总IgE

 

 

显著升高

 

 

■ 7周龄无毛雄性小鼠用Biostir AD处理诱发皮炎模型

141573705409.png

形态学表现

■ 苏木精和曙红对皮肤组织(5 μm)染色(1:500)

141573705463.png

产品列表

产品编号 产品名称 产品规格 产品等级 备注
309-34133 Biostir® AD
Biostir®特应性皮炎诱导剂AD
5 g
303-34131 Biostir® AD
Biostir®特应性皮炎诱导剂AD
15 g

 

 

Biostir® 特应性皮炎诱导剂AD Biostir® AD

Biostir® 特应性皮炎诱导剂AD
Biostir® AD

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

Biostir® 特应性皮炎诱导剂AD                              Biostir® AD

Biostir® 特应性皮炎诱导剂AD

 


产品编号

产品名称

中文名称

包装

备注

309-34133

Biostir® AD

Biostir® 特应性皮炎诱导剂AD

5 g

软膏包括来自粉尘螨的螨过敏原,-30℃

303-34131

Biostir® AD

Biostir® 特应性皮炎诱导剂AD

15 g

项目

方法

动物

特应性皮炎模型服务和药理学测试

 1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir® AD

     诱导特应性皮炎样损伤。

    
 2. 经皮致敏/免疫小鼠。
    
 3. 高概率获得特应性皮炎模型。
    
 4. 评估测试物质对疾病模型的效力。
    
 5. 评价项目:症状评分,IgE,组织病理学,搔抓行为等。

小鼠
(NC/Nga)



◆特征


 ● 是特应性皮炎相关的房尘螨提取物成分之一

 ● Biostir® AD能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤

 ● 在该模型中观察到他克莫司软膏和皮质类固醇软膏的功效

 ● Biostir® AD能高概率在NC/Nga小鼠引起皮炎

 ● Biostir® AD节省时间和精力,与重复应用螨过敏原悬浮液相比较直到观察到皮炎发病

 ● 现今还没有类似概念的产品

 


◆操作流程


  用 4% 十二烷基硫酸钠(SDS)破坏屏障后,每周两次在剃毛的背部皮肤和两耳廓部涂抹100 mg的AD。
  重复此步骤3周。共涂抹6次完成。



◆应用实例


动物

雌性NC / Nga小鼠


特应性皮炎样皮肤损伤的临床方面



在皮肤上观察到搔抓行为,红斑,丘疹,鳞屑,疮痂和苔藓病变


组织学评价

损伤皮肤表现在真皮和表皮显著增厚,角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。


血清总IgE



显著升高


■ 7周龄无毛雄性小鼠用Biostir AD处理诱发皮炎模型

Biostir® 特应性皮炎诱导剂AD                              Biostir® AD

形态学表现

■ 苏木精和曙红对皮肤组织(5 μm)染色(1:500)


Biostir® 特应性皮炎诱导剂AD                              Biostir® AD


参考文献


 1.

Kang, R. Y., Park, B. K., Gim, S. B., Choi, H. J., & Kim, D. H. (2009). The effects of HYT on various immunological factors related to pathogenesis of allergic dermatitis in NC/Nga mice induced by Biostir AD. Journal of Haehwa Medicine, 18(2), 47-62.


 2.

Lee, J. K., Ha, H., Lee, H. Y., Park, S. J., Jeong, S. L., Choi, Y. J., & SHIN, H. K. (2010). Inhibitory effects of heartwood extracts of Broussonetia kazinoki Sieb on the development of atopic dermatitis in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 1007282075-1007282075.


 3.

Lim, H. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. K. (2014). Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice. BMC complementary and alternative medicine, 14(1), 139.


 4.

Aktar, M. K., Kido‐Nakahara, M., Furue, M., & Nakahara, T. (2015). Mutual upregulation of endothelin‐1 and IL‐25 in atopic dermatitis. Allergy, 70(7), 846-854.

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Joo, S. S., Won, T. J., Nam, S. Y., Kim, Y. B., Lee, Y. C., Park, S. Y., … & Lee, D. I. (2009). Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum, in topical application and its activities on atopic dermatitis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(7), 913-919.


 6.

Lim, H. S., Seo, C. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. (2012). Effect of Alpinia katsumadai Hayata on house dust mite-induced atopic dermatitis in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2012.


 7.

Lim, H. S., Ha, H., Lee, M. Y., Jin, S. E., Jeong, S. J., Jeon, W. Y., … & Shin, H. K. (2014). Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice. Food and chemical toxicology, 63, 212-220.


 8.

Kim, M. C., Lee, C. H., & Yook, T. H. (2013). Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. Journal of acupuncture and meridian studies, 6(2), 98-109.


 9.

Lee, J. N., Lee, C. H., & Kim, Y. S. (2015). Protective effects of Opuntia humifusa cladode extracts against biostir AD-induced atopic dermatitis in NC/Nga mice. Food Science and Biotechnology, 24(3), 1123-1130.


10.

Yu, J. S., Kim, J. U., Lee, C. H., Lee, S. R., & Yook, T. H. (2015). The Effects of Lonicerae Flos, Forsythiae Fluctus and Decoction Pharmacopuncture on Atopic Dermatitis in NC/Nga Mice. The Acupuncture, 32(4), 119-131.


11.

Won, T. J., Kim, B., Lim, Y. T., Song, D. S., Park, S. Y., Park, E. S., … & Hwang, K. W. (2011). Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC/Nga mice. Journal of applied microbiology, 110(5), 1195-1202.


12.

Lee, H., Lee, J. K., Ha, H., Lee, M. Y., Seo, C. S., & Shin, H. K. (2012). Angelicae Dahuricae Radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in Nc/Nga mice. Evidence-based Complementary and Alternative Medicine, 2012.


13.

Lee, H., Ha, H., Lee, J. K., Seo, C. S., Lee, N. H., Jung, D. Y., … & Shin, H. K. (2012). The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice. Phytotherapy Research, 26(4), 594-599.


14.

Takeshita, S., Tokunaga, T., Tanabe, Y., Arinami, T., Ichinose, T., & Noguchi, E. (2015). Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice. Allergy, Asthma & Clinical Immunology, 11(1), 3.


15.

Negi, O., Tominaga, M., Tengara, S., Kamo, A., Taneda, K., Suga, Y., … & Takamori, K. (2012). Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. Journal of dermatological science, 66(1), 37-43.

 

16.

Yang, G., Choi, C. H., Lee, K., Lee, M., Ham, I., & Choi, H. Y. (2013). Effects of Catalpa ovata stem bark on atopic dermatitis-like skin lesions in NC/Nga mice. Journal of ethnopharmacology, 145(2), 416-423.


17.

Ha, H., Lee, J. K., Lee, M. Y., Lim, H. S., & Shin, H. (2013). Galgeun-tang, an Herbal Formula, Ameliorates Atopic Dermatitis Responses in Dust Mite Extract-treated NC/Nga Mice. Journal of Korean Medicine, 34(4), 1-11.


18.

Won, T. J., Kim, B., Lee, Y., Bang, J. S., Oh, E. S., Yoo, J. S., … & Park, S. Y. (2012). Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice. Cellular immunology, 277(1-2), 49-57.


19.

Tanaka, K., Ohgo, Y., Katayanagi, Y., Yasui, K., Hiramoto, S., Ikemoto, H., … & Imai, S. (2014). Anti-inflammatory effects of green soybean extract irradiated with visible light. Scientific reports, 4, 4732.


20.

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., … & Suzuki, K. (2014). Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. International immunopharmacology, 23(2), 617-623.


21.

Matsumoto, M., Ebata, T., Hirooka, J., Hosoya, R., Inoue, N., Itami, S., … & Fujita, A. (2014). Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis. Annals of Allergy, Asthma & Immunology, 113(2), 209-216.


22.

Bae, I. H., Yun, J. W., Seo, J. A., Jung, K. M., Kim, K., Noh, M., … & Lim, K. M. (2010). Immunohistological comparison of cutaneous pathology of three representative murine atopic dermatitis models. Journal of dermatological science, 59(1), 57-60.


23.

Ha, H., Lee, H., Seo, C. S., Lim, H. S., Lee, J. K., Lee, M. Y., & Shin, H. (2014). Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice. BMC complementary and alternative medicine, 14(1), 100.


24.

Eto, H., Tsuji, G., Chiba, T., Furue, M., & Hyodo, F. (2017). Non-invasive evaluation of atopic dermatitis based on redox status using in vivo dynamic nuclear polarization magnetic resonance imaging. Free Radical Biology and Medicine, 103, 209-215.


25.

Yun, J. W., Seo, J. A., Jeong, Y. S., Bae, I. H., Jang, W. H., Lee, J., … & Lim, K. M. (2011). TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. Journal of dermatological science, 62(1), 8-15.


26.

Kawahara, T., Tsutsui, K., Nakanishi, E., Inoue, T., & Hamauzu, Y. (2017). Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice. BMC complementary and alternative medicine, 17(1), 80.

27.

Kim, M. S., Kim, J. E., Yoon, Y. S., Kim, T. H., Seo, J. G., Chung, M. J., & Yum, D. Y. (2015). Improvement of atopic dermatitis-like skin lesions by IL-4 inhibition of P14 protein isolated from Lactobacillus casei in NC/Nga mice. Applied microbiology and biotechnology, 99(17), 7089-7099.


28.

Komatsu, K. I., Takanari, J., Maeda, T., Kitadate, K., Sato, T., Mihara, Y., … & Wakame, K. (2016). Perilla leaf extract prevents atopic dermatitis induced by an extract of Dermatophagoides farinae in NC/Nga mice. Asian Pac. J. Allergy Immunol., 34, 272-277.


29.

Sung, Y. Y., Lee, A. Y., & Kim, H. K. (2014). The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo. Journal of ethnopharmacology, 156, 33-40.


30.

Wakame, K., Komatsu, K. I., Inagawa, H., & Nishizawa, T. (2015). Immunopotentiator from Pantoea agglomerans prevents atopic dermatitis induced by Dermatophagoides farinae extract in NC/Nga mouse. Anticancer research, 35(8), 4501-4508.


31.

Ha, H., Lim, H. S., Lee, M. Y., Shin, I. S., Jeon, W. Y., Kim, J. H., & Shin, H. K. (2015). Luffa cylindrica suppresses development of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in Nc/Nga mice. Pharmaceutical biology, 53(4), 555-562.


32.

Fukuyama, T., Tajima, Y., Hayashi, K., Ueda, H., & Kosaka, T. (2011). Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice. Toxicology, 289(2-3), 132-140.


33.

Ignacio, R. M. C., Kwak, H. S., Yun, Y. U., Sajo, M., Yoon, Y. S., Kim, C. S., … & Lee, K. J. (2013). The drinking effect of hydrogen water on atopic dermatitis induced by Dermatophagoides farinae allergen in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2013.


34.

Kumar, P., Hosain, M. Z., Kang, J. H., Takeo, M., Kishimura, A., Mori, T., & Katayama, Y. (2015). Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles. Journal of Biomaterials Science, Polymer Edition, 26(18), 1465-1474.


35.

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., … & Suzuki, K. (2015). Modulation of HMGB 1 translocation and RAGE/NF κB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Experimental dermatology, 24(6), 418-423.


36.

Sung, Y. Y., Kim, D. S., Yang, W. K., Nho, K. J., Seo, H. S., Kim, Y. S., & Kim, H. K. (2012). Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice. Journal of ethnopharmacology, 144(1), 94-100.


37.

Kawasaki, H., Tominaga, M., Shigenaga, A., Kamo, A., Kamata, Y., Iizumi, K., … & Yamakura, F. (2014). Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis. Free Radical Biology and Medicine, 73, 75-83.


38.

Katayanagi, Y., Yasui, K., Ikemoto, H., Taguchi, K., Fukutomi, R., Isemura, M., … & Imai, S. (2013). The clinical and immunomodulatory effects of green soybean extracts. Food chemistry, 138(4), 2300-2305.


39.

Sung, Y. Y., Yoon, T., Jang, J. Y., Park, S. J., & Kim, H. K. (2011). Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice. Journal of Ethnopharmacology, 134(1), 37-44.


40.

Hara, Y., Shoji, J., Hori, S., Ishimori, A., Kato, H., Inada, N., & Sawa, M. (2012). Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. Allergology International, 61(2), 331-338.


41.

Chiba, T., Takeuchi, S., Esaki, H., Yamamura, K., Kurihara, Y., Moroi, Y., & Furue, M. (2012). Topical application of PPAR α (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice. Allergy, 67(7), 936-942.


42.

Sung, Y. Y., Yoon, T., Jang, J. Y., Park, S. J., Jeong, G. H., & Kim, H. K. (2011). Inhibitory effects of Cinnamomum cassia extract on atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice. Journal of Ethnopharmacology, 133(2), 621-628.


43.

Sung, Y. Y., Yang, W. K., Lee, A. Y., Kim, D. S., Nho, K. J., Kim, Y. S., & Kim, H. K. (2012). Topical application of an ethanol extract prepared from Illicium verum suppresses atopic dermatitis in NC/Nga mice. Journal of ethnopharmacology, 144(1), 151-159.


44.

Lee, S. H., Yoon, J. M., Kim, Y. H., Jeong, D. G., Park, S., & Kang, D. J. (2016). Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down‐regulation of immunoglobulin E in NC/Nga mice. Microbiology and immunology, 60(7), 468-476.


45.

Lee, N., Shin, J. U., Jin, S., Yun, K. N., Kim, J. Y., Park, C. O., … & Lee, K. H. (2016). Upregulation of CD47 in regulatory T cells in atopic dermatitis. Yonsei medical journal, 57(6), 1435-1445.


46.

Ha, H., Lee, H., Seo, C. S., Lim, H. S., Lee, M. Y., Lee, J. K., & Shin, H. (2014). Antiatopic Dermatitis Effect of Artemisia iwayomogi in Dust Mice Extract-Sensitized Nc/Nga Mice. Evidence-Based Complementary and Alternative Medicine, 2014.


47.

Kawahara, T., Hanzawa, N., & Sugiyama, M. (2018). Effect of Lactobacillus strains on thymus and chemokine expression in keratinocytes and development of atopic dermatitis-like symptoms. Beneficial microbes, 9(4), 643-652.


48.

Bae, C. J., Lee, J. W., Bae, H. S., Shim, S. B., Jee, S. W., Lee, S. H., … & Hwang, D. Y. (2011). Detection of allergenic compounds using an IL-4/luciferase/CNS-1 transgenic mice model. Toxicological Sciences, 120(2), 349-359.


49.

Kim, B. H., Lee, W. J., Sanjel, B., Cho, K., Son, Y. K., Park, H. Y., … & Shim, W. S. (2019). Extracts of the leaves of Pyrus ussuriensis Maxim. Alleviate itch sensation via TSLP-dependent manner in mouse models of atopic dermatitis. Physiology & behavior, 210, 112624.


50.

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