标签归档：视黄醛

9-cis-Retinal(Synonyms: 9-顺式视黄醛)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

9-cis-Retinal (Synonyms: 9-顺式视黄醛) 纯度: ≥98.0%

9-cis-Retinal 是天然的类视黄醇。饮食中的 99-cis-β-carotene 通过裂解成 9-cis-retinoids 生成 9-cis-Retinal。9-cis-Retinal 与细胞视黄醇结合蛋白-I (CRBP-1) 和 CRBP-II 的 Kd 分别为 8 nM 和 5 nM。9-cis-Retinal 加快了视网膜类器官中杆感光细胞的分化和成熟。

9-cis-Retinal(Synonyms: 9-顺式视黄醛)

9-cis-Retinal Chemical Structure

CAS No. : 514-85-2

规格 价格 是否有货 数量
1 mg ￥2300 In-stock
5 mg   询价  
10 mg   询价  

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生物活性

9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids[1][2][3].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

The addition of 9-cis-Retinal, instead of the widely used all-trans retinoic acid, accelerates rod photoreceptor differentiation in organoid cultures, with higher rhodopsin expression and more mature mitochondrial morphology evident by day. 9-cis-Retinal can bind opsin to form functioning rhodopsin[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Treatment with 9-cis-retinal produced a significant recovery of the cone response in interphotoreceptor retinoid-binding protein (IRBP)-/- mice and shows that retinoid deficiency underlies cone dysfunction[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

284.44

Formula

C20H28O
CAS 号

514-85-2
中文名称

9-顺式视黄醛
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Kane MA, et al. Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.Biochim Biophys Acta. 2011 May;1810(5):514-8.

    [2]. Mertz JR, et al. Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. J Biol Chem. 1997 May 2;272(18):11744-9.

    [3]. Kaya KD, et al. Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal. Mol Vis. 2019 Nov 11;25:663-678.

    [4]. Parker RO, et al. Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci. 2009 Apr 8;29(14):4616-21.