标签归档：苯丙

Methyl Eugenol

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Methyl Eugenol  纯度: 98.64%

Methyl Eugenol 是一种存在于植物叶子、果实、茎和/或根中的苯丙类化合物，当植物相应的部位因食草动物进食而受损时，就会释放。Methyl Eugenol可用于消灭雄性东方果蝇。

Methyl Eugenol

Methyl Eugenol Chemical Structure

CAS No. : 93-15-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly[1].

分子量

178.23

Formula

C11H14O2
CAS 号

93-15-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (561.07 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.6107 mL 28.0536 mL 56.1073 mL
5 mM 1.1221 mL 5.6107 mL 11.2215 mL
10 mM 0.5611 mL 2.8054 mL 5.6107 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (14.03 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (14.03 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (14.03 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Tan KH, et al. Methyl eugenol: its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination. J Insect Sci. 2012;12:56.

Secoisolariciresinol(Synonyms: 开环异落叶松树脂酚)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Secoisolariciresinol (Synonyms: 开环异落叶松树脂酚) 纯度: 98.89%

Secoisolariciresinol 是一种木脂素，属于苯丙素类。

Secoisolariciresinol(Synonyms: 开环异落叶松树脂酚)

Secoisolariciresinol Chemical Structure

CAS No. : 29388-59-8

规格 价格 是否有货 数量
5 mg ￥4030 In-stock
10 mg ￥6860 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

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生物活性

Secoisolariciresinol is a lignan, a type of phenylpropanoids.

Clinical Trial

分子量

362.42

Formula

C20H26O6
CAS 号

29388-59-8
中文名称

开环异落叶松树脂酚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (275.92 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7592 mL 13.7961 mL 27.5923 mL
5 mM 0.5518 mL 2.7592 mL 5.5185 mL
10 mM 0.2759 mL 1.3796 mL 2.7592 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Eva Tavčar Benković, et al. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract. Journal of Wood Chemistry and Technology. 2017 Jan, 467-477.

5,7-Dihydroxy-4-methylcoumarin

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

5,7-Dihydroxy-4-methylcoumarin  纯度: 98.97%

5,7-Dihydroxy-4-methylcoumarin 是墨西哥龙蒿中的一种香豆素衍生物。5,7-Dihydroxy-4-methylcoumarin 有抗真菌和抗细菌活性。

5,7-Dihydroxy-4-methylcoumarin

5,7-Dihydroxy-4-methylcoumarin Chemical Structure

CAS No. : 2107-76-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities[1].

分子量

192.17

Formula

C10H8O4
CAS 号

2107-76-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (130.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2037 mL 26.0186 mL 52.0373 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL
10 mM 0.5204 mL 2.6019 mL 5.2037 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.01 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.01 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Céspedes CL1, et al. Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). J Agric Food Chem. 2006 May 17;54(10):3521-7.

3′-​O-​Acetylhamaudol

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

3′-​O-​Acetylhamaudol  纯度: 99.87%

3′-O-Acetylhamaudol 是从Angelica japonica 根部提取得到的，其抗肿瘤活性通过抗血管生成和激活肠上皮淋巴细胞实现。

3

3′-​O-​Acetylhamaudol Chemical Structure

CAS No. : 30358-88-4

规格 价格 是否有货 数量
5 mg ￥3160 In-stock
10 mg ￥5380 In-stock
20 mg ￥9140 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

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生物活性

3′-O-Acetylhamaudol, isolated from Angelica japonica roots, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation[1].

分子量

318.32

Formula

C17H18O6
CAS 号

30358-88-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Kimura Y, et al. Anti-tumor actions of major component 3′-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. Cancer Lett. 2008 Jun 28;265(1):84-97.

Yangambin

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Yangambin  纯度: ≥98.0%

Yangambin 是一种呋喃木脂素 (furofuran lignan)，已经从诸如番荔枝科 (Annonaceae family) 的植物中分离出来，包括：R. pickeli，R. exalbida 和 R. mucosa 以及 Magnolia biondii。 Yangambin 是一种选择性 PAF 受体拮抗剂，通过调控 Ca2+ 通道抑制 Ca2+ 流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少。Yangambin 表现出对 β-氨基己糖苷酶 (β-hexosaminidase) 的抗过敏活性，IC50 为 33.8 μM，抗炎活性的 IC50 为 37.4 μM。

Yangambin

Yangambin Chemical Structure

CAS No. : 13060-14-5

规格 价格 是否有货 数量
5 mg ￥8800 In-stock
10 mg ￥15000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

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生物活性

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2].

IC50 & Target[1]

Ca2+

 

分子量

446.49

Formula

C24H30O8
CAS 号

13060-14-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Araújo IG, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19(5):6863-76.

    [2]. Jindaporn Puripattanavong, et al. Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves. Songklanakarin J. Sci. Technol. 2015,37 (1), 37-41.

3′-Hydroxyxanthyletin

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

3′-Hydroxyxanthyletin 

3′-Hydroxyxanthyletin 是一种香豆素化合物，具有抗分枝杆菌活性。

3

3′-Hydroxyxanthyletin Chemical Structure

CAS No. : 165900-08-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

3′-Hydroxyxanthyletin is a coumarin compound with antimycobacterial activities[1][2].

体外研究
(In Vitro)

3′-Hydroxyxanthyletin against Mycobacterium tuberculosis H37RV in vitro with a MIC value of 16 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

244.24

Formula

C14H12O4
CAS 号

165900-08-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li-Wen Chen, et al. Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa. Chem Biodivers. 2010 Jul;7(7):1814-21.

    [2]. Satyajit D.Sarker, et al. An alkaloid, coumarins and a triterpene from Boronia algida. Phytochemistry. Volume 39, Issue 4, July 1995, Pages 801-804.

Oxypeucedanin

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Oxypeucedanin  纯度: 98.03%

Oxypeucedanin 是从 Angelica dahurica 中分离出来的呋喃香豆素衍生物。Oxypeucedanin 是一种选择性的开放通道阻滞剂，可抑制 hKv1.5 通道电流，IC50 值为 76 nM。Oxypeucedanin 延长心脏动作电位持续时间 (APD)，是一种潜在的抗心律失常试剂。Oxypeucedanin 通过抑制癌细胞迁移来诱导细胞凋亡 (apoptosis )。

Oxypeucedanin

Oxypeucedanin Chemical Structure

CAS No. : 737-52-0

规格 价格 是否有货 数量
5 mg ￥2020 In-stock
10 mg ￥3430 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

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生物活性

Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

IC50 & Target

IC50: HKv1.5 current; apoptosis[1]
分子量

286.28

Formula

C16H14O5
CAS 号

737-52-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (174.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4931 mL 17.4654 mL 34.9308 mL
5 mM 0.6986 mL 3.4931 mL 6.9862 mL
10 mM 0.3493 mL 1.7465 mL 3.4931 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.73 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.73 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60.

    [2]. Yu Liu, et al. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration

Matairesinol

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Matairesinol 

Matairesinol 在过敏性皮炎小鼠模型中具有抗过敏作用。Dfe 诱导的 NC/Nga 小鼠耳内 IL-4 和 IFN-γ mRNA 表达的变化可通过应用 Matairesinol 逆转。

Matairesinol

Matairesinol Chemical Structure

CAS No. : 580-72-3

规格 价格 是否有货
5 mg ￥6900 询问价格 & 货期

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生物活性

Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application[1].

IC50 & Target

Human Endogenous Metabolite

 

分子量

358.39

Formula

C20H22O6
CAS 号

580-72-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sung YY, Lee AY, Kim HK. Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model. J Ethnopharmacol. 2016;187:49-56.