标签归档：神经肽

GR231118 TFA(Synonyms: 1229U91 TFA GW1229 TFA)

发表于由

GR231118 TFA;(Synonyms: 1229U91 TFA; GW1229 TFA)

GR231118 是神经肽 Y 的 C 末端的类似物，对人神经肽 Y Y 受体具有较强的竞争性和相对选择性拮抗剂，其拮抗剂的 pKi 为10.4。GR231118 是人类神经肽 Y4 受体 (pEC50=8.6; pKi=9.6) 和对人及大鼠神经肽 YY2 和 Y5 受体的弱激动剂。GR231118 对小鼠神经肽 YY6 受体也有较高亲和力 (pKi= 8.8)。

GR231118 TFAamp;;(Synonyms: 1229U91 TFA; GW1229 TFA)

GR231118 TFA Chemical Structure

规格 是否有货
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生物活性

GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8)[1].

分子量

2466.76

Formula

C112H171F3N34O26
Sequence Shortening

Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1′:IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4′;Dpr4-Glu2′)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol

    [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.

(Des-Br)-NPB-29 (Human) 人神经肽B-29 品牌：Anygen

发表于由

(Des-Br)-NPB-29 (Human)

人神经肽B-29

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

303-91651

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

GR231118(Synonyms: 1229U91 GW1229)

发表于由

GR231118;(Synonyms: 1229U91; GW1229)

GR231118 是神经肽Y 的 C 末端的类似物，对人神经肽 Y Y 受体具有较强的竞争性和相对选择性拮抗剂，其拮抗剂的 pKi 为10.4。GR231118 是人类神经肽 Y4 受体 (pEC50=8.6; pKi=9.6) 和对人及大鼠神经肽 YY2 和 Y5 受体的弱激动剂。GR231118 对小鼠神经肽 YY6 受体也有较高亲和力 (pKi= 8.8)。

GR231118amp;;(Synonyms: 1229U91; GW1229)

GR231118 Chemical Structure

CAS No. : 158859-98-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].

分子量

2352.74

Formula

C110H170N34O24
CAS 号

158859-98-4
Sequence Shortening

Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1′:IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4′;Dpr4-Glu2′)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol

    [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.

Neuropeptide S (human)(Synonyms: 神经肽S (人类))

发表于由

Neuropeptide S (human);(Synonyms: 神经肽S (人类))

Neuropeptide S human，一种神经肽，是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human 可用于阿尔茨海默病 (AD) 的研究。

Neuropeptide S (human)amp;;(Synonyms: 神经肽S (人类))

Neuropeptide S (human) Chemical Structure

CAS No. : 412938-67-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer’s disease (AD) research[1].

IC50 Target

EC50: 9.4 nM (neuropeptide S receptor)[1]
体外研究
(In Vitro)

Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively[1].
Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC50 of 6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM)[1].
Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS, [125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice[1]
Dosage: 0.1 nM, 1 nM
Administration: Intracerebroventricular (i.c.v.) injection
Result: Increased locomotor activity and promoted wakefulness.

分子量

2187.50

Formula

C93H155N31O28S
CAS 号

412938-67-1
Sequence

Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
Sequence Shortening

SFRNGVGTGMKKTSFQRAKS
中文名称

神经肽S (人类)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.

Neuropeptide Y (human) monoclonal antibody (8) 神经肽 Y（人）单抗（8） 品牌：Enzo

发表于由

Neuropeptide Y (human) monoclonal antibody (8)

神经肽 Y（人）单抗（8）

品牌：Enzo
CAS No.：
储存条件：+4℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BPD-ABS-028-08-1

 – 1 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Neuropeptide Y (human) monoclonal antibody (8) 神经肽 Y（人）单抗（8） 品牌：Enzo

发表于由

Neuropeptide Y (human) monoclonal antibody (8)

神经肽 Y（人）单抗（8）

品牌：Enzo
CAS No.：
储存条件：+4℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BPD-ABS-028-08-04

 – 400 µg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。