标签归档：活性

Psoralenoside

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Psoralenoside;

Psoralenoside 是源于 Psoralea corylifolia 中的一种苯并呋喃苷。Psoralenoside 对组胺 H1、钙调素和电压门控 l 型钙通道 (E-value≥-6.5 Kcal/mol) 具有较高的亲和力。Psoralenoside 具有雌激素样活性、促进成骨细胞增殖活性、抗肿瘤活性和抗菌活性。

Psoralenoside

Psoralenoside Chemical Structure

CAS No. : 905954-17-8

规格 是否有货
5 mg 询价
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生物活性

Psoralenoside is a benzofuran glycoside from Psoralea corylifolia[1]. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol)[2]. Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity[3].

IC50 Target[1]

H1 Receptor

;

L-type calcium channel

;

分子量

366.32

Formula

C17H18O9
CAS 号

905954-17-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chun-Feng Qiao, et al.Psoralenoside and isopsoralenoside, two new benzofuran glycosides from Psoralea corylifolia. Chem Pharm Bull (Tokyo). 2006 May;54(5):714-6.

    [2]. Muhammad Bilal Riaz, et al. Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders. BMC Complement Altern Med. 2019 Dec 3;19(1):348.

    [3]. Yue-Fei Wang, et al.A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract. J Ethnopharmacol

Isopsoralenoside

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Isopsoralenoside;

Isopsoralenoside 是补骨脂多糖中的一种苯并呋喃苷。Isopsoralenoside 在消化道内容物中可迅速代谢为补骨脂素 (HY-N0053)。Isopsoralenoside 具有雌激素样活性、促进成骨细胞增殖活性、抗肿瘤活性和抗菌活性。

Isopsoralenoside

Isopsoralenoside Chemical Structure

CAS No. : 905954-18-9

规格 是否有货
5 mg 询价
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25 mg 询价

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生物活性

Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity[1].

分子量

366.32

Formula

C17H18O9
CAS 号

905954-18-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yue-Fei Wang, et al.A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract. J Ethnopharmacol

Anemarsaponin E

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Anemarsaponin E; 纯度: ge;99.0%

Anemarsaponin E 是从 Anemarrhena asphodeloides 中提取的皂苷，并具有抗炎活性。

Anemarsaponin E

Anemarsaponin E Chemical Structure

CAS No. : 136565-73-6

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity.

分子量

935.10

Formula

C46H78O19
CAS 号

136565-73-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Yang B, et al. Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2018 Jan 30;148:119-127.

Nociceptin(1-7)

发表于由

Nociceptin(1-7);

Nociceptin(1-7) 是 Nociceptin (HY-P0183) 的 N 端生物活性片段。Nociceptin(1-7) 是一种有效的 ORL1 (NOP) 受体激动剂，具有缓解疼痛活性。Nociceptin (1-7) 联合 Nociceptin 可降低体内对痛觉的敏感。

Nociceptin(1-7)amp;;

Nociceptin(1-7) Chemical Structure

CAS No. : 178249-42-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

体内研究
(In Vivo)

Nociceptin (1-7) (intrathecal injection; 150–1200  nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 150–1200  nmol
Administration: Intrathecal injection; single dose
Result: Co-treatment with nociceptin could reduce hyperalgesia.

分子量

655.70

Formula

C31H41N7O9
CAS 号

178249-42-8
Sequence Shortening

FGGFTGA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. T Sakurada, et al. Nociceptin (1 – 7) antagonizes nociceptin-induced hyperalgesia in mice.Br J Pharmacol. 1999 Nov;128(5):941-4.

(R)-Eucomol

发表于由

天然产物 黄酮类 Flavonoids

(R)-Eucomol 

(R)-Eucomol 是一种类黄酮衍生物，显示出微弱的抗菌活性。(R)-Eucomol 对 KB 和 P-388 细胞显示出细胞毒活性。

(R)-Eucomol

(R)-Eucomol Chemical Structure

CAS No. : 118204-64-1

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

(R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells[1].

分子量

316.31

Formula

C17H16O6
CAS 号

118204-64-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. TRADITIONAL MEDICINAL PLANTS OF THAILAND XIII. FLAVONOID DERIVATIVES FROM DRACAENA LOUREIRI ( AGAVACEAE)*

α-Terpineol(Synonyms: α-松油醇)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

α-Terpineol (Synonyms: α-松油醇) 纯度: ≥98.0%

α-Terpineol 从蓝桉 (Eucalyptus globulus Labill) 中分离出来，对牙周病和致龋菌具有很强的抗菌活性。 α-Terpineol 具有抗真菌活性 T. mentagrophytes，这种活性可能导致不可逆转的细胞分裂。

α-Terpineol(Synonyms: α-松油醇)

α-Terpineol Chemical Structure

CAS No. : 98-55-5

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

α-Terpineol 相关产品

•相关化合物库:

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  • Immunology/Inflammation Compound Library
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  • Terpenoids Library
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  • Inactive Ingredient Library

生物活性

α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria[1]. α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption[2].

分子量

154.25

Formula

C10H18O
CAS 号

98-55-5
中文名称

α-松油醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 250 mg/mL (1620.75 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.4830 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL
10 mM 0.6483 mL 3.2415 mL 6.4830 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (13.48 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (13.48 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (13.48 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (13.48 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (13.48 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (13.48 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Park SN, et al. Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria. Anaerobe. 2012 Jun;18(3):369-72.

    [2]. Park MJ, et al. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. Fitoterapia. 2009 Jul;80(5):290-6.

Phillyrin

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Phillyrin  纯度: 98.99%

Phillyrin 是从连翘中分离出来的，具有抗菌和消炎作用。Phillyrin 对大鼠 CYP1A2 和 CYP2D1 具有潜在的诱导作用，而不会影响 CYP2C11 和 CYP3A1/2 活性。Phillyrin 具有抗甲型流感病毒的活性。

Phillyrin

Phillyrin Chemical Structure

CAS No. : 487-41-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥588 In-stock
5 mg ￥500 In-stock
10 mg ￥800 In-stock
20 mg ￥1400 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Phillyrin 相关产品

•相关化合物库:

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  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
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  • Antioxidants Compound Library
  • Glycoside Compound Library
  • Oxygen Sensing Compound Library
  • Antibacterial Compound Library
  • Anti-COVID-19 Compound Library
  • NMPA-Approved Drug Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved & Pharmacopeial Drug Library

生物活性

Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1]. Phillyrin has anti-influenza A virus activities[2].

IC50 & Target

CYP1A2; CYP2D1[1]
体外研究
(In Vitro)

Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells[1].
Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Human HepG2 hepatocyte cells
Concentration: 1 μM; 2.5 μM; 5 μM
Incubation Time: 24 hours
Result: Reduced FAS and SREBP-1c mRNA expression.

分子量

534.55

Formula

C27H34O11
CAS 号

487-41-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 260 mg/mL (486.39 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8707 mL 9.3537 mL 18.7073 mL
5 mM 0.3741 mL 1.8707 mL 3.7415 mL
10 mM 0.1871 mL 0.9354 mL 1.8707 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution

    此方案可获得 ≥ 2.17 mg/mL (4.06 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution

    此方案可获得 ≥ 2.17 mg/mL (4.06 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution

    此方案可获得 ≥ 2.17 mg/mL (4.06 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Cheng Y, et al. Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro. Xenobiotica. 2017 Apr;47(4):297-303.

    [2]. Qu XY, et al. Protective effects of phillyrin against influenza A virus in vivo. Arch Pharm Res. 2016 Jul;39(7):998-1005.

    [3]. Do MT, et al. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food Chem. 2013 Jan 15;136(2):415-25.

Sideroxylin

发表于由

天然产物 黄酮类 Flavonoids

Sideroxylin 

Sideroxylin 是一种从 Callistemon lanceolatus 中分离的 C-甲基化黄酮，对金黄色葡萄球菌具有抗菌活性。Sideroxylin 可抑制卵巢癌细胞增殖并诱导凋亡 (apoptosis)，导致 DNA 断裂，线粒体膜去极化，产生活性氧 (ROS)。

Sideroxylin

Sideroxylin Chemical Structure

CAS No. : 3122-87-0

规格 价格 是否有货
5 mg ￥19000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species (ROS)[1].

分子量

312.32

Formula

C18H16O5
CAS 号

3122-87-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sunwoo Park, et al. Sideroxylin (Callistemon Lanceolatus) Suppressed Cell Proliferation and Increased Apoptosis in Ovarian Cancer Cells Accompanied by Mitochondrial Dysfunction, the Generation of Reactive Oxygen Species, and an Increase of Lipid Peroxidation. J Cell Physiol. 2018 Nov;233(11):8597-8604.

whatman酶活性检测纸1号滤纸1001-085

发表于由

whatman酶活性检测纸1号滤纸

简要描述：

定性滤纸
Whatman定性滤纸用于定性分析技术中鉴定物质的性质。折
叠好的定性滤纸与相同型号平整的滤纸相比，加快了流速和
增加了负载力。
定性滤纸―标准级
Grade 1 : 11 μm
No1滤纸是*使用zui广泛和历史zui悠久的一种化学分
析滤纸，拥有中等保留能力和流速。
规格从直径10 mm到500 mm圆片以及460 × 570 mm的矩形。
这个级别覆盖了大部分实验室应用范围，经常用于液体澄清。
也被传统的用于沉淀物的定性分析分离，例如硫酸铅、草酸
钙(热)和碳酸钙，它是纤维素酶活性、钻井液活性粘土、防
护布抗性、青霉素测定用标准滤纸。
在农业方面，它被用于土壤分析和种子测试。在食品工业方
面，Grade 1滤纸常用于从相关液体中分离固体食品或者抽
提液体，也广泛用于教学中简单的定性分析分离。
在空气污染物监测方面，有圆片和卷状可供使用，从大气中
收集大气灰尘然后用光度计来测量污染程度。在气体探测中，
滤纸用发色剂浸润，通过光反射来进行定量。Whatman 1号
滤纸应用是作为微流控芯片基体，了现代分析技术
的发展方向。

whatman酶活性检测纸1号滤纸

whatman酶活性检测纸1号滤纸1001-085whatman酶活性检测纸1号滤纸1001-085