标签归档：洋地黄

Digitonin(Synonyms: 洋地黄皂苷)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Digitonin;(Synonyms: 洋地黄皂苷) 纯度: ge;98.0%

Digitonin 是从洋地黄中提取的糖苷，可通过与胆固醇分子结合来增加细胞膜的通透性，并能抑制肿瘤生长。Digitonin 是一种天然去垢剂。

Digitonin(Synonyms: 洋地黄皂苷)

Digitonin Chemical Structure

CAS No. : 11024-24-1

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥550 In-stock
25 mg ￥500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Digitonin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Glycoside Compound Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved amp; Pharmacopeial Drug Library

生物活性

Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth[1]. Digitonin is an natural detergent[2].

体外研究
(In Vitro)

Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1229.31

Formula

C56H92O29
CAS 号

11024-24-1
中文名称

洋地黄皂苷；毛地黄皂苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, stored under nitrogen

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (81.35 mM; Need ultrasonic)

DMSO : 100 mg/mL (81.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8135 mL 4.0673 mL 8.1346 mL
5 mM 0.1627 mL 0.8135 mL 1.6269 mL
10 mM 0.0813 mL 0.4067 mL 0.8135 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lindnér PG, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol. 1997;40(5):444-8.

    [2]. Leendert van Dalsen, et al. In meso Crystallogenesis. Compatibility of the Lipid Cubic Phase With the Synthetic Digitonin Analogue, Glyco-Diosgenin. J Appl Crystallogr. 2020 Mar 25;53(Pt 2):530-535.