4”-methyloxy-Genistin, an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities[1].
分子量
446.40
Formula
C22H22O10
CAS 号
950910-16-4
中文名称
4”-甲氧基染料木苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Park DK, et al. Antiallergic activity of novel isoflavone methyl-glycosides from Cordyceps militaris grown on germinated soybeans in antigen-stimulated mast cells. J Agric Food Chem. 2012 Mar 7;60(9):2309-15.
Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects[1][2].
体外研究 (In Vitro)
Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats[1]
Dosage:
26.8 mg/kg
Administration:
Intraperitoneal injection; 26.8 mg/kg; 14 days
Result:
Exhibited neuroprotective effects in rats.
分子量
446.40
Formula
C22H22O10
CAS 号
20633-67-4
中文名称
毛蕊异黄酮苷;毛蕊异黄酮苷;毛蕊异黄酮-7-O-β-D 葡萄糖苷
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Shuping Fu, et al. Calycosin-7-O-β-D-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury. J Ethnopharmacol. 2014 Aug 8;155(1):692-701.
[2]. Xiangli Yan, et al. Calycosin-7- O- β- D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1 α Pathway in HT22 Cells. Neural Plast. 2019 Dec 1;2019:8798069.
Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity. IC50 value: Target: in vitro: calycosin had obvious anti-proliferation effects on SKOV3 cells in a dose- and time-dependent manner. calycosin up-regulated the Bax/Bcl-2 ratio and cleaved caspase-3, cleaved caspase-9 expression in a dose-dependent manner. In summary, calycosin might exert anti-growth and induce-apoptosis activity against ovarian cancer SKOV3 cells through activating caspases and Bcl-2 family proteins, therefore presenting as a promising therapeutic agent for the treatment of ovarian cancer [1]. Both calycosin and genistein inhibited proliferation and induced apoptosis in MCF-7 breast cancer cells, especially after treatment with calycosin. Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR [2]. incubation of calycosin resulted in enhanced expression ERβ in MCF-7 and T-47D cells, rather than MDA-231 and MDA-435 cells. Moreover, with the upregulation of ERβ, successive changes in downstream signaling pathways were found, including inactivation of insulin-like growth factor 1 receptor (IGF-1R), then stimulation of p38 MAPK and suppression of the serine/threonine kinase (Akt), and finally poly(ADP-ribose) polymerase 1 (PARP-1) cleavage [3]. in vivo: calycosin stimulated a dramatic increase in uterine weight and downregulated the level of ERα protein in OVX mice [4].
分子量
284.26
Formula
C16H12O5
CAS 号
20575-57-9
中文名称
毛蕊异黄酮;异黄酮
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12.
[2]. Chen J, et al. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8.
[3]. Chen J, et al. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. PLoS One. 2014 Mar 11;9(3):e91245.
[4]. Chen J, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308(2):144-51.
Luteone is a natural isoflavone, with antioxidant, antibacterial and antifung activities[1].
体外研究 (In Vitro)
Luteone exhibits significant antibacterial activity with minimum inhibitory quantity (MIQ) values of 1.88 µg, 1.88 µg and 3.75 µg, respectively, against sensitive (MSSA) and resistant strains (MRSA and MDRSA) of S. aureus[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
354.35
Formula
C20H18O6
CAS 号
41743-56-0
中文名称
羽扇豆异黄酮
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Kaisarun Akter, et al. Antimicrobial and antioxidant activity and chemical characterisation of Erythrina stricta Roxb. (Fabaceae). J Ethnopharmacol. 2016 Jun 5;185:171-81.
Glycitin is a natural isoflavone isolated from legumes; promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.Glycitin is antibacterial, antiviral and estrogenic.
分子量
446.40
Formula
C22H22O10
CAS 号
40246-10-4
中文名称
黄豆黄苷;黄豆黄甙;大豆黄苷
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Uesugi T, et al. Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. Biol Pharm Bull. 2001 Apr;24(4):368-72.
[2]. Li XH, et al. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin. 2005 Sep;26(9):1081-6.
[3]. Zhang L, et al. Glycitin regulates osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells. Exp Ther Med. 2016 Nov;12(5):3063-3067.
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation[1][2][3][4][5].
IC50 & Target
DNA polymerase[4]
体外研究 (In Vitro)
Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED50=25 μM) and cytokine (ED50s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages[1]. Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED50 of 19.94 μM in activated RAW264.7 cells[1]. Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells[1]. Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner[2]. Neobavaisoflavone (2-8 μM; 7 d) inhibits RANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
[1]. Szliszka E, et, al. Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages. Molecules. 2011 May 3;16(5):3701-12.
[2]. Szliszka E, et, al. Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia. Pharmacol Rep. 2011;63(1):139-48.
[3]. Chen H, et, al. Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-κB, MAPK and Akt pathways. J Cell Mol Med. 2020 Aug;24(16):9067-9084.
[4]. Sun NJ, et, al. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J Nat Prod. 1998 Mar;61(3):362-6.
[5]. Tsai WJ, et, al. Antiplatelet flavonoids from seeds of Psoralea corylifolia. J Nat Prod. 1996 Jul;59(7):671-2.
7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).
IC50 & Target
AMPK[1]
体外研究 (In Vitro)
7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK). When serum-starved cells are treated with 10 % FBS in the presence of 7-methoxyisoflavone, the serum-induced decrease in AMPK phosphorylation is prevented[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
252.26
Formula
C16H12O3
CAS 号
1621-56-3
中文名称
7-甲氧基异黄酮
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Hyeryoung Jung, et al. Isoflavones as modulators of adenosine monophosphate-activated protein kinase. Applied Biological Chemistry. 2016. 59, 217-225.
Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase[1].
分子量
354.35
Formula
C20H18O6
CAS 号
116709-70-7
中文名称
西北甘草异黄酮
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Li W, et al. Bioassay-guided isolation and quantification of the alpha-glucosidase inhibitory compound, glycyrrhisoflavone, from Glycyrrhiza uralensis. Nat Prod Commun. 2010 Jul;5(7):1049-53.
6”-O-Acetylglycitin, a acetyl glucoside, is one of the isoflavone isomer in soybeans, shows various extents of content reduction dependent on storage temperature, packaging condition, and its isoflavone isomer kind[1].
分子量
488.44
Formula
C24H24O11
CAS 号
134859-96-4
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Huang RY, et al. Stability of isoflavone isomers in steamed black soybeans and black soybean koji stored under different conditions. J Agric Food Chem. 2009 Mar 11;57(5):1927-32.
Licoisoflavone B 是一种异黄酮类化合物。Licoisoflavone B 抑制脂质过氧化,IC50 为 2.7 μM。
Licoisoflavone B Chemical Structure
CAS No. : 66056-30-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Licoisoflavone B is an isoflavone[1]. Licoisoflavone B inhibits lipid peroxidation with an IC50 of 2.7 μM.
分子量
352.34
Formula
C20H16O6
CAS 号
66056-30-2
中文名称
甘草异黄酮 B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Li D, et al. The Application of Ultra-High-Performance Liquid Chromatography Coupled with a LTQ-Orbitrap Mass Technique to Reveal the Dynamic Accumulation of Secondary Metabolites in Licorice under ABA Stress. Molecules. 2017 Oct 20;22(10). pii: E1742.
[2]. S. Toda, et al. Inhibitory Effects of Isoflavones in Sophora mooracrotiana on Lipid Peroxidation by Superoxide. Pharmaceutical Biology. 2002, 40 (6):422-424.