iMatrix-511

iMatrix-511 silk

生产系统

转基因 CHO-S 细胞

转基因蚕生产系统

提纯材料

CHO-S 细胞培养上清

蚕蛹蛋白

产品等级

实验研究用* *有临床用级别

实验研究用

导入基因

人层粘连蛋白 511-E8 片段

纯度

95% 以上

浓度

0.5 mg/mL

解离常数

10 nM 以下

使用期限

生产后 2 年内

iPS 细胞培养能力

添加 0.5 μg/cm² 到培养容器中，可用于 iPS 细胞的维持培养

175 µg×2

（350 µL×2)

175 µg×6

（350 µL×6)

产品

保质期

iMatrix-511

自生产后两年内

iMatrix-511silk

自生产后两年内

iMatrix-511MG

自生产后两年内

分类

文献信息

主题

人多能干细胞（hPSC）的确立

Miyazaki et al. Nat. Commun.3:1236, (2012)

证实用作hPSC的培养基质的有效性

Nakagawa et al. Sci. Rep. 4:3594, (2014)

确立医疗等级的hPSC

Takashima et al. Cell.158(6):1254-69, (2014)

促进向hPSC的基质状态的转移

Miyazaki et al. Sci. Rep.7:41165, (2017)

采用无需涂层操作的添加法培养hPSC

Sekine et al. Stem Cell Res.24:40-43, (2017)

确立疾病特异性的hPSC

Tan et al. Stem Cell Res. 24:12-15, (2017)

Ishida et al. Sci. Rep. 8(1), 310, (2018)

利用hPSC的基因编辑建立遗传性疾病模型

Kim et al. Nature Communications, 9(1), 939, (2018)

Sakai-Takemura et al. Sci. Rep, 8, 6555, (2018)

悬浮培养由hPSC分化的肌肉前体细胞

由hPSC分化衍生的细胞

Doi et al. Stem Cell Reports. 2(3):337-50, (2014)

多巴胺产生神经元

Ishikawa et al. Hum. Mol. Genet.25(23):

5188-5197, (2016)

Nishimura et al. Stem Cell Reports.6(4):

511-524, (2016)

Samata et al. Nat. Commun. 7:13097, (2016)

Kikuchi et al. Nature. 548(7669):592-596, 　　(2017)

Morizane et al. Nat. Commun.8(1):385, (2017)

Kikuchi et al. J. Neurosci. Res.95(9):1829-37, (2017)

Goparaju et al. Sci. Rep. 7:42367, (2017)

运动神经元

Burridge et al. Nat. Methods.11(8):855-60, 　  (2014)

心肌细胞

Sougawa et al. Sci. Rep,8(1), 3726, (2018)

Yamauchi et al. BBRC, 495(1), 1278-1284, 　    (2018)

心室肌细胞

Akiyama et al. Sci. Rep, 8(1), 1189, (2018)

骨骼肌细胞

Saito et al. Stem Cell Res Ther, 9(1), 12, (2018)

成骨细胞

Uchimura et al. Stem cell research, 25, 98-106, (2017)

成肌细胞

Hayashi et al. Nature.531(7594):376-80, (2016)

视觉细胞

Hayashi et al. Nat. Protoc.12(4):683-696, (2017)

角膜上皮细胞

Takayama et al. BBRC. 474(1):91-96, (2016)

胆管上皮细胞

Takayama et al. Hepatol Commun,1(10), 1058-1069, (2017)

肝实质细胞

Takayama et al. Biomaterials, (2018)

Takebe et al. Cell Reports, 21(10), 2661-2670, (2017)

肝细胞

Tan et al. Stem Cell Reports, 11:1-11, (2018)

Camp et al. Nature. 546(7659):533-38, (2017)

定形内胚层细胞

Zhang et al. Stem Cell Reports, 10(2), 1–14, (2018)

后内胚层前体细胞

Tanigawa et al. Cell reports, 15(4), 801-813, (2016)

肾单位前体细胞（胎肾细胞）

Musah et al. Nat.Biomed.Eng.1:0069, (2017)

肾小球上皮细胞

Musah et al. Nature protocols,13(7):1662, 　  (2018)

Mae et al. BBRC, 495(1), 954-961, (2018)

输尿管芽组织

Oshima et al. BBRC, 497(2), 719-725, (2018)

血细胞・血管内皮常见前体细胞

Taguchi et al. Cell Stem Cell, 21, (2017) 

*培养hPSC用于分化肾单位前体细胞（胎肾细胞）

Kawamura et al. Stem Cell Reports.6(3):312-20,(2016)

*培养hPSC用于分化心肌细胞

Sasaki et al. Cell Stem Cell.17(2):178-94, (2015)

*培养hPSC用于分化生殖细胞

Kojima et al. Cell Stem Cell.21(4):517-532, 　  (2017)

Furuta et al. PLoS One. 9(12):e112291, (2014)

*培养hPSC用于分化间充质细胞

人原代细胞的培养

Okumura et al. Invest. Ophth. Vis. Sci.56(5):2933-42, (2015)

人角膜内皮细胞

Hongo et al. Invest. Ophth. Vis. Sci.58(9):3325-34, (2017)

Polisetti et al. Sci. Rep.7(1):5152, (2017)

人角膜边缘上皮前体细胞

Ishii et al. Stem Cell Reports, 10, 1-15, (2018)

卫星细胞

层粘连蛋白-整合素相互作用的分子机制

Ido et al. J. Biol. Chem. 282(15): 11144-54, 　  (2007)

Ido et al. J. Biol. Chem.283(42): 28149-57, 　  (2008)

Taniguchi et al. J. Biol. Chem. 284(12): 7820-31, (2009)

Taniguchi et al. BBRC.487(3): 525-531, (2017)

Takizawa et al. Sci Adv.3(9) :e1701497, (2017)

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