标签归档：一枝黄花

Polygalacic acid(Synonyms: 毛果一枝黄花皂苷元G)

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Polygalacic acid (Synonyms: 毛果一枝黄花皂苷元G) 纯度: 98.92%

Polygalacic acid 毛果一枝黄花皂苷元 G 是一种三萜，是从远志 Polygala tenuifolia Willd 根中分离出来的。 Polygalacic acid 抑制 MMP 表达。 Polygalacic acid 可以用于骨关节炎 (OA) 相关研究。 Polygalacic acid 对认知障碍有显着的神经保护作用，PA 通过抑制乙酰胆碱酯酶 (AChE) 活性，增加胆碱乙酰转移酶(ChAT) 活性，提高海马和额皮质中的乙酰胆碱 (Ach) 水平来提高胆碱能系统反应性。

Polygalacic acid(Synonyms: 毛果一枝黄花皂苷元G)

Polygalacic acid Chemical Structure

CAS No. : 22338-71-2

规格 价格 是否有货 数量
1 mg ￥2800 In-stock
5 mg ￥8500 询价
10 mg   询价  
50 mg   询价  

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生物活性

Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].

体外研究
(In Vitro)

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1].
Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 24 hours
Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis[1]

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 6 hours
Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

分子量

504.70

Formula

C30H48O6
CAS 号

22338-71-2
中文名称

毛果一枝黄花皂苷元G
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252.

    [2]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55.