N-Hexanoylsphingosine 品牌：FUJIFILM Wako

发表于2024年11月13日由Whatman官网

N-Hexanoylsphingosine

品牌：FUJIFILM Wako
CAS No.：
储存条件： –
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
082-07001	–	10 mg	–		–	–

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2-Furoyl-LIGRLO-amide TFA

发表于2024年11月13日由Whatman官网

2-Furoyl-LIGRLO-amide TFA;

2-Furoyl-LIGRLO-amide TFA 是一种有效的选择性蛋白酶激活受体2 (PAR2) 激动剂，其 pD₂ 值为 7.0。

2-Furoyl-LIGRLO-amide TFA Chemical Structure

规格	价格	是否有货
1 mg	￥1200	询问价格货期
5 mg	￥3600	询问价格货期
10 mg	￥6120	询问价格货期

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2-Furoyl-LIGRLO-amide TFA 的其他形式现货产品:

2-Furoyl-LIGRLO-amide

生物活性

2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD₂ value of 7.0^[1]^[2]..

IC₅₀ Target

Proteinase-activated receptor 2 (PAR2)^[1]

体外研究
(In Vitro)

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is equally effective to and 10 to 25 times more potent than SLIGRLNH₂ for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively^[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is 10 to 300 times more potent than SLIGRL-NH₂. Unlike trans-cinnamoyl-LIGRLO-NH₂, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3^-/- mice. But it decreases significantly the number of scratches in WT mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male (2/3-month-old) Trpv3^-/- and WT mice^[2]
Dosage:	10 μg
Administration:	Injected intradermally at the nape of the neck
Result:	Was involved in PAR2- induced acute itch.

分子量

891.98

Formula

C₃₈H₆₄F₃N₁₁O₁₀

Sequence

{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

Sequence Shortening

{Fur-2-oyl}-LIGRL-{Orn}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.

[2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87.

[3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol