分类目录归档：多肽产品

CCZ01048

发表于由

CCZ01048;

CCZ01048 是一种 α-MSH 类似物，与黑素皮质素 1 受体 (MC1R) 具有很高的结合亲和力，Ki 值为 0.31 nM。CCZ01048 具有快速内化 B16F10 黑色素瘤细胞和高体内稳定性。CCZ01048 是恶性黑色素瘤 PET 显像的一个有前途的制剂。

CCZ01048amp;;

CCZ01048 Chemical Structure

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生物活性

CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma[1].

体内研究
(In Vivo)

The cationic Pip linker to Nle-CycMSHhex, CCZ01048, not only improves tumor uptake, but also generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1508.72

Formula

C71H105N21O16
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang C, et al. Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET. Theranostics. 2017;7(4):805-813. Published 2017 Feb 8.

Scabioside C

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Scabioside C;

Scabioside C 是总次生皂苷 (TSS) 的一种主要三萜皂苷。TSS 来自 A. raddeana，具有潜在的抗乳腺癌效果。

Scabioside C

Scabioside C Chemical Structure

CAS No. : 17233-22-6

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生物活性

Scabioside C is a main triterpenoid saponin for total secondary saponin (TSS). TSS, from A. raddeana, exhibits the potential anti-breast cancer effect[1].

分子量

766.95

Formula

C41H66O13
CAS 号

17233-22-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dandan Zhang, et al. Anti-breast Cancer and Toxicity Studies of Total Secondary Saponin From Anemone Raddeana Rhizome on MCF-7 Cells via ROS Generation and PI3K/AKT/mTOR Inactivation. J Ethnopharmacol. 2020 Sep 15;259:112984.

ZIP TFA

发表于由

ZIP TFA;

ZIP TFA 是一种选择性的 PKMζ 肽抑制剂。 ZIP TFA 可以阻止吗啡条件性位置偏爱诱导的损伤。

ZIP TFAamp;;

ZIP TFA Chemical Structure

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ZIP TFA 的其他形式现货产品:

ZIP

生物活性

ZIP TFA is a selective peptide inhibitor of PKMζ. ZIP TFA injections can block the impairment in morphine conditioned place preference induced[1].

IC50 Target

PKMζ[1]
Clinical Trial

分子量

2042.40

Formula

C92H155F3N30O19
Sequence Shortening

{Myr-Ser}-IYRRGARRWRKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Li Y, et, al. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31(14):5436-46.

Clematichinenoside C

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Clematichinenoside C;

Clematichinenoside C 是存在于裂叶铁线莲中的一种三萜皂苷.

Clematichinenoside C

Clematichinenoside C Chemical Structure

CAS No. : 177912-24-2

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生物活性

Clematichinenoside C is one of triterpenoid saponins found in Clematis parviloba[1].

分子量

1499.63

Formula

C70H114O34
CAS 号

177912-24-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yan LH, Xu LZ, Lin J, Yang SL, Feng YL. Triterpenoid saponins from the stems of Clematis parviloba. J Asian Nat Prod Res. 2009;11(4):332-338.

Allatostatin II

发表于由

Allatostatin II;

Allatostatin II 是一种十肽。Allatostatin 是一种多效性神经肽，用于抑制昆虫保幼激素合成。

Allatostatin IIamp;;

Allatostatin II Chemical Structure

CAS No. : 123374-34-5

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生物活性

Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects[1].

分子量

1067.20

Formula

C49H74N14O13
CAS 号

123374-34-5
Sequence

Gly-Asp-Gly-Arg-Leu-Tyr-Ala-Phe-Gly-Leu-NH2
Sequence Shortening

GDGRLYAFGL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Stay B, et al. The role of allatostatins in juvenile hormone synthesis in insects and crustaceans. Annu Rev Entomol. 2007;52:277-99.

Camelliaside A(Synonyms: 山茶苷 A)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Camelliaside A;(Synonyms: 山茶苷 A)

Camelliaside A 是来自茶 (Camellia oleifera) 种子残渣甲醇提取物中的一种类黄酮。

Camelliaside A(Synonyms: 山茶苷 A)

Camelliaside A Chemical Structure

CAS No. : 135095-52-2

规格 价格 是否有货 数量
5 mg ￥3700 In-stock
10 mg ￥6290 In-stock
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Camelliaside A 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Glycoside Compound Library
  • Phenols Library
  • Flavonoids Library

生物活性

Camelliaside A is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace[1].

分子量

756.66

Formula

C33H40O20
CAS 号

135095-52-2
中文名称

山茶苷 A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
参考文献

  • [1]. Kuo PC, et al. Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. J Agric Food Chem. 2010 Aug 11;58(15):8618-22.

PKI(5-24) TFA

发表于由

PKI(5-24) TFA;

PKI(5-24) TFA 是一种强效、竞争性、合成的 PKA (cAMP 依赖性蛋白激酶) 抑制剂，Ki 为 2.3 nM。PKI(5-24) TFA 对应于天然存在的热稳定蛋白激酶抑制剂中的 5-24 残基。

PKI(5-24) TFAamp;;

PKI(5-24) TFA Chemical Structure

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PKI(5-24) TFA 的其他形式现货产品:

PKI(5-24)

生物活性

PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

体外研究
(In Vitro)

PKI(5-24) TFA is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein[1].
PKI(5-24) TFA inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2336.40

Formula

C94H148N32O31.C2HF3O2
Sequence

Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp
Sequence Shortening

TTYADFIASGRTGRRNAIHD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261(3):989-992.

    [2]. Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996;377(7-8):513-520.

Soyasaponin Ba(Synonyms: 大豆皂苷Ba)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin Ba;(Synonyms: 大豆皂苷Ba)

Soyasaponin Ba 是一种从菜豆类中分离出的大豆皂苷，能作为醛糖还原酶抑制剂 (ARI)。

Soyasaponin Ba(Synonyms: 大豆皂苷Ba)

Soyasaponin Ba Chemical Structure

CAS No. : 114590-20-4

规格 价格 是否有货
5 mg ￥2020 询问价格 货期
10 mg ￥3430 询问价格 货期

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生物活性

Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI)[1].

分子量

959.12

Formula

C48H78O19
CAS 号

114590-20-4
中文名称

大豆皂苷Ba
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):350-360.

Cyclo(Ala-Glu)

发表于由

Cyclo(Ala-Glu);

Cyclo(Ala-Glu) 是一种环状二肽。

Cyclo(Ala-Glu)amp;;

Cyclo(Ala-Glu) Chemical Structure

CAS No. : 16364-36-6

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生物活性

Cyclo(Ala-Glu) is a cyclic dipeptide[1].

分子量

200.19

Formula

C8H12N2O4
CAS 号

16364-36-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Takashi Mizuma, et al. Uptake of Cyclic Dipeptide by PEPT1 in Caco-2 Cells: Phenolic Hydroxyl Group of Substrate Enhances Affinity for PEPT1. J Pharm Pharmacol. 2002 Sep;54(9):1293-6.

Salirepin

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Salirepin;

Salirepin 是一种酚苷类物质，从 Idesia polycarpa 的果实中获得，能够抑制脂多糖诱导的一氧化氮的产生。

Salirepin

Salirepin Chemical Structure

CAS No. : 26652-12-0

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生物活性

Salirepin is a phenolic glycoside from fruits of Idesia polycarpa, inhibits LPS-induced nitric oxide production[1].

分子量

302.28

Formula

C13H18O8
CAS 号

26652-12-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim SH, et al. Inhibitory activity of phenolic glycosides from the fruits of Idesia polycarpa on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Planta Med. 2007 Feb;73(2):167-9. Epub 2006 Nov 24.