分类目录归档：多肽产品

Spadin

发表于由
回复

Spadin;

Spadin 是一种从血液中释放的前肽衍生的天然肽，能够阻断 TREK-1 (KCNK2 或 K2P2.1) 通道的活性。Spadin 与 TREK-1 特异性结合，亲和力为 10 nM。Spadin 是一种有效的抗抑郁药。

Spadinamp;;

Spadin Chemical Structure

CAS No. : 1270083-24-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Spadin 的其他形式现货产品:

Spadin TFA

生物活性

Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice[1].

分子量

2012.34

Formula

C96H142N26O22
CAS 号

1270083-24-3
Sequence Shortening

YAPLPRWSGPIGVSWGLR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Jean Mazella, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.

Ginsenoside C-Y(Synonyms: Ginsenoside Y)

发表于由
回复

天然产物 糖类和糖苷 Saccharides and Glycosides

Ginsenoside C-Y;(Synonyms: Ginsenoside Y)

Ginsenoside C-Y 是天然的抗氧化剂，具有抗光老化和抗黑素生成活性。

Ginsenoside C-Y(Synonyms: Ginsenoside Y)

Ginsenoside C-Y Chemical Structure

CAS No. : 83480-65-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Ginsenoside C-Y, a natural antioxidant, possesses antiphotoaging and antimelanogenesis activities[1].

分子量

754.99

Formula

C41H70O12
CAS 号

83480-65-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiao-Yi Liu, et al. Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C-Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD-ginsenoside. Photochem Photobiol. 2019 Nov;95(6):1412-1423.

OVA (55-62)

发表于由

OVA (55-62);

OVA (55-62) 是一种来自卵白蛋白 (ovalbumin) 的一个片段，可与小鼠 MHC I 类分子 H2-Kb 结合。

OVA (55-62)amp;;

OVA (55-62) Chemical Structure

CAS No. : 151992-56-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

OVA 55-62 is a fragmented peptide of OVA (ovalbumin) antigen and can bind to the mouse MHC class I molecule, H2-Kb[1].

分子量

1004.30

Formula

C47H81N13O11
CAS 号

151992-56-2
Sequence

Lys-Val-Val-Arg-Phe-Asp-Lys-Leu
Sequence Shortening

KVVRFDKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. G B Lipford, et al.Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif. J Immunol. 1993 Feb 15;150(4):1212-22.

Curculigoside B

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Curculigoside B;

Curculigoside B 是从虎杖中分离得到的酚苷类化合物，能促进成骨细胞增殖，减少骨吸收坑面积，减少破骨细胞形成和 TRAP 活性。具有抗骨质疏松和抗氧化活性。

Curculigoside B

Curculigoside B Chemical Structure

CAS No. : 143601-09-6

规格 价格 是否有货
1 mg ￥2000 询问价格 货期

* Please select Quantity before adding items.

生物活性

Curculigoside B, a phenolic glycoside isolated from Curculigo orchioides, enhances the osteoblast proliferation, decreases the area of bone resorption pit, osteoclastic formation and TRAP activity. Antiosteoporotic and antioxidative activities[1].

分子量

452.41

Formula

C21H24O11
CAS 号

143601-09-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jiao L, et al. Antiosteoporotic activity of phenolic compounds from Curculigo orchioides. Phytomedicine. 2009;16(9):874-881.

Prosaptide Tx14(A) TFA

发表于由

Prosaptide Tx14(A) TFA;

Prosaptide Tx14(A) TFA 是一种 prosaposin 衍生肽，是一种有效的 GPR37L1 和 GPR37 激动剂，EC50 分别为 5 和 7 nM。Prosaptide Tx14(A) TFA 增加 Schwann 细胞 ERK1 和 ERK2 的磷酸化。

Prosaptide Tx14(A) TFAamp;;

Prosaptide Tx14(A) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Prosaptide Tx14(A) TFA 的其他形式现货产品:

Prosaptide Tx14(A)

生物活性

Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

体外研究
(In Vitro)

Prosaptide Tx14(A) TFA promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) TFA is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1693.72

Formula

C71H111F3N16O28
Sequence

Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr
Sequence Shortening

TALIDNNATEEILY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534.

    [2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314.

Stipuleanoside R2

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Stipuleanoside R2;

Stipuleanoside R2 对 TNFα 刺激下 NF-κB 的活化具有剂量依赖性，其IC50值为 4.1μM。

Stipuleanoside R2

Stipuleanoside R2 Chemical Structure

CAS No. : 96627-72-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Stipuleanoside R2 inhibits NF-κB activation stimulated by TNFα in a dose-dependent manner with IC50 value of 4.1 μM[1].

分子量

1089.22

Formula

C53H84O23
CAS 号

96627-72-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nhiem NX, Lim HY, Kiem PV, et al. Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway. Bioorg Med Chem Lett. 2011;21(20):6143-6147.

[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)

发表于由

[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153);

[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) 与胰岛素结合，可作为胰岛素受体酪氨酸激酶底物。

[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)amp;;

[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) Chemical Structure

CAS No. : 141171-54-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) binds to insulin and can be used as insulin receptor tyrosine kinase substrates[1].

分子量

1862.67

Formula

C72H110N19O33P3
CAS 号

141171-54-2
Sequence Shortening

TRDI-{pTyr}-ETD-{pTyr}-{pTyr}-RK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Shintani T, et al. The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J Biochem. 2015 Sep;158(3):235-43.

Lucidin primeveroside(Synonyms: Lucidin 3-O-β-primeveroside)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Lucidin primeveroside;(Synonyms: Lucidin 3-O-β-primeveroside)

Lucidin primeveroside (Lucidin 3-O-β-primeveroside) 是一种存在于茜草根中的蒽醌衍生物，已被用作着色剂和食品添加剂。Lucidin primeveroside 可以代谢转化为基因毒性化合物 Lucidin，随后形成 Lucidin 特异性 DNA 加合物。

Lucidin primeveroside(Synonyms: Lucidin 3-O-β-primeveroside)

Lucidin primeveroside Chemical Structure

CAS No. : 29706-59-0

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts[1][2].

体内研究
(In Vivo)

Lucidin primeveroside (0.3% in the diet; 4 weeks or 13 weeks) induces Lucidin-specific DNA adduct formation and increases mutation frequencies in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

564.49

Formula

C26H28O14
CAS 号

29706-59-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yockey OP, et, al. Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ. Chem Res Toxicol. 2017 Nov 20;30(11):2023-2032.

    [2]. Ishii Y, et, al. Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin-3-O-primeveroside. J Appl Toxicol. 2019 Apr;39(4):650-657.

CCZ01048

发表于由

CCZ01048;

CCZ01048 是一种 α-MSH 类似物，与黑素皮质素 1 受体 (MC1R) 具有很高的结合亲和力，Ki 值为 0.31 nM。CCZ01048 具有快速内化 B16F10 黑色素瘤细胞和高体内稳定性。CCZ01048 是恶性黑色素瘤 PET 显像的一个有前途的制剂。

CCZ01048amp;;

CCZ01048 Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma[1].

体内研究
(In Vivo)

The cationic Pip linker to Nle-CycMSHhex, CCZ01048, not only improves tumor uptake, but also generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1508.72

Formula

C71H105N21O16
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang C, et al. Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET. Theranostics. 2017;7(4):805-813. Published 2017 Feb 8.

Scabioside C

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Scabioside C;

Scabioside C 是总次生皂苷 (TSS) 的一种主要三萜皂苷。TSS 来自 A. raddeana，具有潜在的抗乳腺癌效果。

Scabioside C

Scabioside C Chemical Structure

CAS No. : 17233-22-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Scabioside C is a main triterpenoid saponin for total secondary saponin (TSS). TSS, from A. raddeana, exhibits the potential anti-breast cancer effect[1].

分子量

766.95

Formula

C41H66O13
CAS 号

17233-22-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dandan Zhang, et al. Anti-breast Cancer and Toxicity Studies of Total Secondary Saponin From Anemone Raddeana Rhizome on MCF-7 Cells via ROS Generation and PI3K/AKT/mTOR Inactivation. J Ethnopharmacol. 2020 Sep 15;259:112984.