Urocortin, rat TFA;(Synonyms: Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA)
Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) 是一种神经肽，也是一种有效的内源性 CRFR 激动剂，对人 CRF1，大鼠 CRF2α 和小鼠 CRF2β 的 Ki 分别为 13 nM，1.5 nM 和 0.97 nM。
Urocortin, rat TFA Chemical Structure
| 规格 | 是否有货 | ||
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| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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| 生物活性 |
Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively[1][2]. |
IC50 Target |
Ki: 13 nM (Human CRF1), 1.5 nM (Rat CRF2α), and 0.97 nM (Mouse CRF2β)[1] |
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| 体外研究 (In Vitro) |
Urocortin, rat induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively in stably transfected Chinese hamster ovary cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
4821.28 |
| Formula |
C208H339N62F3O66 |
| Sequence Shortening |
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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