Apelin-17(human, bovine) TFA

发表于由

Apelin-17(human, bovine) TFA;

Apelin-17(human, bovine) TFA是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-17(human, bovine) TFA 与在 HEK 293 细胞中表达的人 APJ 受体结合 (pIC50)。Apelin-17(human, bovine) TFA 阻断 HIV-1 和 HIV-2 毒株进入表达 APJ 的 NP-2/CD4 细胞。

Apelin-17(human, bovine) TFAamp;;

Apelin-17(human, bovine) TFA Chemical Structure

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Apelin-17(human, bovine) TFA 的其他形式现货产品:

Apelin-17(human, bovine)

生物活性

Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

IC50 Target[3]

HIV-1

;

HIV-2

;

分子量

2252.57

Formula

C98H157F3N34O22S
Sequence

Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

KFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

    [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

    [3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.