Caloxin 2A1

发表于由

Caloxin 2A1;

Caloxin 2A1 是一种细胞外质膜 Ca2+-ATPase (PMCA) 肽抑制剂。Caloxin 2A1 不影响基础 Mg2+-ATPase 或 Na+-K+-ATPase。

Caloxin 2A1amp;;

Caloxin 2A1 Chemical Structure

CAS No. : 350670-85-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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Caloxin 2A1 的其他形式现货产品:

Caloxin 2A1 TFA

生物活性

Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg2+-ATPase or Na+-K+-ATPase[1].

体外研究
(In Vitro)

Caloxin 2A1 inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts, but it does not affect basal Mg2+-ATPase or Na+-K+-ATPase in the ghosts or Ca2+-Mg2+-ATPase in the skeletal muscle sarcoplasmic reticulum. Caloxin 2A1 also inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate[1].
Caloxin 2A1 increases airway smooth muscle cells (ASMCs) apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1478.52

Formula

C64H91N19O22
CAS 号

350670-85-8
Sequence Shortening

VSNSNWPSFPSSGGG-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J Chaudhary, et al. Caloxin: a novel plasma membrane Ca2+ pump inhibitor. Am J Physiol Cell Physiol. 2001 Apr;280(4):C1027-30.

    [2]. Yi-fei Chen, et al. Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and the proliferation of airway smooth muscle cells. Eur J Pharmacol. 2014 Oct 5;740:733-41.