hMC1R agonist 1

发表于由

hMC1R agonist 1;

hMC1R agonist 1 是一种有效的选择性 hMC1R 激动剂(EC50=3 nM)，hMC1R agonist 1 对 hMC1R 的选择性是 hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), 和 hMC5R (b>EC50=>1000 nM) 的 300 倍。hMC1R agonist 1 有治疗和预防黑皮质素家族疾病的潜能。

hMC1R agonist 1amp;;

hMC1R agonist 1 Chemical Structure

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生物活性

(EC50=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family[1].

IC50 Target

EC50: 3 nM (hMC1R); 902 nM (hMC3R); 915 nM (hMC4R)[1]
分子量

1107.35

Formula

C54H70N14O8S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nafie MS, et al. Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer. Bioorg Chem. 2022; 122:105708.