Angiopeptin;(Synonyms: 血管抑肽)
Angiopeptin 是生长抑素的环状八肽类似物，是一种 sst2/sst5 受体部分激动剂，IC50 值分别为 0.26 nM 和 6.92 nM。Angiopeptin 可以抑制生长激素释放和胰岛素样生长因子-1 (IGF-1) 产生。Angiopeptin 抑制腺苷酸环化酶或刺激细胞外酸化。Angiopeptin 具有用于冠状动脉粥样硬化研究的潜力。
Angiopeptin Chemical Structure
CAS No. : 113294-82-9
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
Angiopeptin 的其他形式现货产品:
| 生物活性 |
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research[1][2]. |
IC50 Target |
IC50: 0.26 nM (sst2) and 6.92 nM (sst5)[1][2] |
|---|---|
| 体外研究 (In Vitro) |
Angiopeptin (0.1 nM- 10 μM; for 1 h) acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst2 cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
Angiopeptin (20 and 50μg/kg; i.h.) significantly inhibits neointimal formation[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
1098.34 |
| Formula |
C54H71N11O10S2 |
| CAS 号 |
113294-82-9 |
| Sequence Shortening |
{Nal}CYWKVCT-NH2 |
| 中文名称 |
血管抑肽 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
|