JTP10-△-TATi TFA

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JTP10-△-TATi TFA;

JTP10-△-TATi TFA 是选择性的 JNK2 多肽抑制剂，其IC50 值为 92 nM，对 JNK2 的选择性是JNK1 和 JNK3 的10倍以上。

JTP10-△-TATi TFAamp;;

JTP10-△-TATi TFA Chemical Structure

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生物活性

JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC50 of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3[1].

IC50 Target[1]

JNK2

92 nM (IC50)

JNK1

1.16 mu;M (IC50)

JNK3

1.2 mu;M (IC50)

体外研究
(In Vitro)

JTP10-△-TATi TFA inhibits the migration of PyVMTjnk2+/+ cells and PyVMTjnk2-/- cells expressing GFP-JNK2α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2833.28

Formula

C120H213F3N48O28
Sequence Shortening

Ac-PKRPTTLNLF-{Ahx}-RRRQRRKKRG-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Tamer S. Kao, et al. Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration. ACS Chem Biol. 2011 Jun 17;6(6):658-66.