Autocamtide-2-related inhibitory peptide

Autocamtide-2-related inhibitory peptide;

Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptideamp;;

Autocamtide-2-related inhibitory peptide Chemical Structure

CAS No. : 167114-91-2

规格 是否有货
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Autocamtide-2-related inhibitory peptide 的其他形式现货产品:

Autocamtide-2-related inhibitory peptide TFA

生物活性

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

IC50 Target

IC50: 40 nM (CaMKII)[1].

体外研究
(In Vitro)

It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1497.74

Formula

C64H116N22O19

CAS 号

167114-91-2

Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Sequence Shortening

KKALRRQEAVDAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.