Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat(Synonyms: MOG (35-55))

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat;(Synonyms: MOG (35-55))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。还能诱导强效的 T细胞和 B 细胞反应，同时是高度脑源性的。

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, ratamp;;(Synonyms: MOG (35-55))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Chemical Structure

CAS No. : 149635-73-4

规格 价格 是否有货
1 mg ￥1500 询问价格 货期
5 mg ￥4500 询问价格 货期
10 mg ￥7600 询问价格 货期

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 的其他形式现货产品:

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA

生物活性

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces strong T and B cell responses and is highly encephalitogenic[1][2][3].

体内研究
(In Vivo)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG) is a highly autoantigenic molecule capable of inducing severe demyelinating disease[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred female NOD/Lt (H-P’), C57BL/6 (H-2b), C57BL/10 (H-2′), DBAj2 (H-2d), BALB/c (H-2″), BALB/c (H-2b), C3H/HeJ (H-2k), BI0.Br (H-2k), BI0.S (H-2′), SJL/J (H-2′) and PL/J (H-2″) mice[2]
Dosage: 50 μg (100 μg total).
Administration: Injected in each hind footpad.
Result: Mice receiving 50 μg and 100 μg of peptide has more dramatic weight losses during the course of the disease than mice injected with 150 μg.

分子量

2581.95

Formula

C118H177N35O29S
CAS 号

149635-73-4
Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ichikawa M, et al. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J Immunol. 1996 Jul 15;157(2):919-26.

    [2]. Slavin A, et al. Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity. 1998;28(2):109-20.

    [3]. Zhang GX, et al. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice. J Neuroimmunol. 2004 Mar;148(1-2):1-10.