CALP3 TFA;
CALP3 TFA 是一种类似于 Ca2+ 的肽,是有效的 Ca2+ 通道阻滞剂,可激活 Ca2+ 结合蛋白的 EF 手。CALP3 TFA 可以通过调节钙调蛋白 (CaM),Ca2+ 通道和泵的活性来模拟增加的 [Ca2+]i。CALP3 TFA 具有控制诸如艾滋病或由于缺血引起的神经元丢失等疾病中细胞凋亡的潜力。
![CALP3 TFA Chemical Structure CALP3 TFAamp;;](http://file.medchemexpress.cn/product_pic/hy-p1075a.gif)
CALP3 TFA Chemical Structure
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100 mg | ; | 询价 | ; |
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生物活性 |
CALP3 TFA, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2]. |
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IC50 Target[1][2] |
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体外研究 (In Vitro) |
CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50=37.25 μM) in Fura-2-loaded neuronal cultures[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
995.10 |
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Formula |
C46H69F3N10O11 |
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Sequence Shortening |
VKFGVGFK |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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