Norleual;
Norleual 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子 (HGF)/c-Met 抑制剂,IC50 为 3 pM。Norleual 还是一种 AT4 拮抗剂,具有强大的抗血管生成活性。
Norleual Chemical Structure
CAS No. : 334994-34-2
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生物活性 |
Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities[1]. |
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体外研究 (In Vitro) |
Norleual at 20 and 50 pM significantly reduces HGF-dependent c-Met and Gab1 phosphorylation. 20 pM Norleual dramatically reduces HGF-initiated association between Gab1 and c-Met in HEK293 cells. Norleual markedly attenuates HGF-dependent c-Met activation and downstream signaling[1]. Norleual (1 pM-1 μM; 4 days) is able to inhibit HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types at concentrations in the picomolar range in MDCK cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
Norleual (50 μg/kg; intraperitoneal injection; daily; for 2 weeks; C57BL/6 mice) suppresses pulmonary colonization by B16-F10 murine melanoma cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
774.95 |
Formula |
C41H58N8O7 |
CAS 号 |
334994-34-2 |
Sequence Shortening |
{Nle}-Y-{Leu-(CH2-NH2)}-HPF |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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