KYL peptide

发表于由

KYL peptide;

KYL peptide 是一种拮抗肽，可选择性靶向 EphA4。KYL peptide 与 EphA4 的配体结合域结合，有效缓解 Aβ 诱导的 AD 小鼠突触功能障碍和突触可塑性缺陷。KYL peptide 可促进损伤后神经再生，调节免疫反应。

KYL peptideamp;;

KYL peptide Chemical Structure

CAS No. : 676657-00-4

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生物活性

KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor. KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2].

IC50 Target

EphA4 receptor[1]
体外研究
(In Vitro)

KYL peptide blocks the extracellular ligand-binding domain of EphA4, abolishes the Aβ-stimulated EphA4 tyrosine phosphorylation[2].
KYL peptide abolishes the Aβ-triggered reduction of dendritic spines in cultured hippocampal neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1465.73

Formula

C74H108N14O17
CAS 号

676657-00-4
Sequence Shortening

KYLPYWPVLSSL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445(1):47-56.

    [2]. Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64.