Beta-defensin 1, pig(Synonyms: 猪 β-防御素1)

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Beta-defensin 1, pig;(Synonyms: 猪 β-防御素1)

Beta-defensin 1, pig 是主要在猪舌黏膜中发现的一种抗菌肽。Beta-defensin 1, pig 对大肠杆菌，鼠伤寒沙门氏菌，单核细胞增生性李斯特菌，金黄色葡萄球菌，百日咳博德特氏菌和白色念珠菌等细菌具有活性。

Beta-defensin 1, pigamp;;(Synonyms: 猪 β-防御素1)

Beta-defensin 1, pig Chemical Structure

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生物活性

Beta-defensin 1, pig is an antimicrobial peptide found primarily in tongue mucosa of pig. Beta-defensin 1, pig is active against bacteria such as Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, Bordetella pertussis and Candida albicans[1][2].

IC50 Target

Bacterial[1]
体外研究
(In Vitro)

Expression of beta-defensin (pBD-1) mRNA increased from the proximal to the distal part of the intestine whereas pBD-2 expression decreased. The main gene expression sites for pBD-2 are kidney and liver, whereas pBD-1 is mainly expressed in tongue[1].
An eight-fold increase in pBD-1 mRNA expression is observed upon S. typhimurium infection in the porcine intestinal cell line IPEC J2[1].
Porcine beta-defensin 1 (pBD-1) also has immunomodulatory activity in porcine peripheral blood mononuclear cells and lymph node cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Resistance against respiratory infection with B. pertussis in older piglets is associated with the presence of Porcine beta-defensin 1 (pBD-1) in the upper respiratory tract. Furthermore, treatment with pBD-1 conferred complete protection of newborn piglets from intrapulmonary infection with B. pertussis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

7410.90

Formula

C321H534N92O90S9
Sequence

Met-Arg-Ala-Leu-Cys-Leu-Leu-Leu-Leu-Thr-Val-Cys-Leu-Leu-Ser-Ser-Gln-Leu-Ala-Ala-Gly-Ile-Asn-Leu-Leu-Thr-Gly-Leu-Gly-Gln-Arg-Ser-Asp-His-Tyr-Ile-Cys-Ala-Lys-Lys-Gly-Gly-Thr-Cys-Asn-Phe-Ser-Pro-Cys-Pro-Leu-Phe-Asn-Arg-Ile-Glu-Gly-Thr-Cys-Tyr-Ser-Gly-Lys-Ala-Lys-Cys-Cys-Ile-Arg
Sequence Shortening

MRALCLLLLTVCLLSSQLAAGINLLTGLGQRSDHYICAKKGGTCNFSPCPLFNRIEGTCYSGKAKCCIR
中文名称

猪 β-防御素1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Edwin J A Veldhuizen , et al. Expression of Beta-Defensins pBD-1 and pBD-2 Along the Small Intestinal Tract of the Pig: Lack of Upregulation in Vivo Upon Salmonella Typhimurium Infection. Mol Immunol. 2007 Jan;44(4):276-83.

    [2]. D R Pruthviraj, et al. Identification of a Novel Single Nucleotide Polymorphism in Porcine Beta-Defensin-1 Gene. Asian-Australas J Anim Sci. 2016 Mar;29(3):315-20.

    [3]. Shokrollah Elahi, et al. The Host Defense Peptide Beta-Defensin 1 Confers Protection Against Bordetella Pertussis in Newborn Piglets. Infect Immun. 2006 Apr;74(4):2338-52.